TY - JOUR
T1 - Lifestyle interventions affecting hepatic fatty acid metabolism
AU - Parry, Sion A.
AU - Turner, Mark C.
AU - Hodson, Leanne
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Purpose of review Prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing, and as pharmacological treatment does not exist, lifestyle interventions (i.e. diet and exercise) represent the cornerstone management and treatment strategy. Although the available data clearly demonstrate that changes in lifestyle influence intrahepatic triglyceride (IHTG) content, the mechanisms through which this is achieved are seldom investigated. Here, we review recent evidence demonstrating the influence of lifestyle interventions on hepatic fatty acid metabolism and IHTG content.Recent findingsDiet and exercise influence IHTG content through various, and often interrelated factors. These include alterations in whole-body and tissue-specific insulin sensitivity, which may influence the flux of fatty acid and lipogenic substrates to the liver, and changes in intrahepatic fatty acid synthesis and partitioning. Notably, there are only a few studies that have investigated intrahepatic fatty acid metabolism in vivo in humans before and after an intervention.SummaryLifestyle interventions represent an effective means of influencing hepatic fatty acid metabolism. IHTG content is decreased without weight-loss either through exercise or by changing the macronutrient composition of the diet, although what the optimal macronutrient composition is to achieve this has yet to be defined.
AB - Purpose of review Prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing, and as pharmacological treatment does not exist, lifestyle interventions (i.e. diet and exercise) represent the cornerstone management and treatment strategy. Although the available data clearly demonstrate that changes in lifestyle influence intrahepatic triglyceride (IHTG) content, the mechanisms through which this is achieved are seldom investigated. Here, we review recent evidence demonstrating the influence of lifestyle interventions on hepatic fatty acid metabolism and IHTG content.Recent findingsDiet and exercise influence IHTG content through various, and often interrelated factors. These include alterations in whole-body and tissue-specific insulin sensitivity, which may influence the flux of fatty acid and lipogenic substrates to the liver, and changes in intrahepatic fatty acid synthesis and partitioning. Notably, there are only a few studies that have investigated intrahepatic fatty acid metabolism in vivo in humans before and after an intervention.SummaryLifestyle interventions represent an effective means of influencing hepatic fatty acid metabolism. IHTG content is decreased without weight-loss either through exercise or by changing the macronutrient composition of the diet, although what the optimal macronutrient composition is to achieve this has yet to be defined.
KW - diet
KW - exercise
KW - hepatic fatty acid metabolism
KW - metabolic-associated fatty liver disease
KW - nonalcoholic fatty liver disease
UR - http://www.scopus.com/inward/record.url?scp=85092750158&partnerID=8YFLogxK
UR - https://journals.lww.com/co-clinicalnutrition/abstract/2020/11000/lifestyle_interventions_affecting_hepatic_fatty.2.aspx
U2 - 10.1097/MCO.0000000000000687
DO - 10.1097/MCO.0000000000000687
M3 - Review article
C2 - 32833701
AN - SCOPUS:85092750158
SN - 1363-1950
VL - 23
SP - 373
EP - 379
JO - Current Opinion in Clinical Nutrition and Metabolic Care
JF - Current Opinion in Clinical Nutrition and Metabolic Care
IS - 6
ER -