TY - JOUR
T1 - Low cytotoxicity, antibacterial property, and curcumin delivery performance of toughness-enhanced electrospun composite membranes based on poly(lactic acid) and MAX phase (Ti3AlC2)
AU - Krasian , Tharnthip
AU - Punyodom, Winita
AU - Molloy, Robert
AU - Topham, Paul
AU - Tighe, Brian
AU - Mahomed, Anisa
AU - Chaiwarit , Tanpong
AU - Panraksa , Pattaraporn
AU - Rachtanapun , Pornchai
AU - Jantanasakulwong , Kittisak
AU - Worajittiphon, Patnarin
N1 - Copyright © 2023, Elsevier. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/
PY - 2024/3
Y1 - 2024/3
N2 - MXenes, synthesized from their precursor MAX phases, have been extensively researched as additives to enhance the drug delivery performance of polymer matrices, whereas there is a limited number of previous reports on the use of MAX phases themselves for such applications. The use of MAX phases can exclude the complicated synthesis procedure and lessen resultant production and environmental costs required to convert MAX phases to MXenes. Herein, electrospun membranes of poly(lactic acid) (PLA) and a MAX phase (Ti3AlC2) have been fabricated for curcumin delivery. The composite membrane exhibits significantly higher toughness (8.82 MJ m-3) than the plasticized PLA membrane (0.63 MJ m-3) with low cytotoxicity, supporting proliferation of mouse fibroblast L929 cells. The curcumin-loaded composite membrane exhibits high water vapor transmission (~7350 g m-2 day-1), porosity (~85 %), water wettability, and antibacterial properties against E. coli and S. aureus. Seven-day curcumin release is enhanced from 45 % (PLA) to 67 % (composite) due to curcumin diffusion from the polymer fibers and MAX phase surface that contributes to overall increased curcumin adsorption and release sites. This work demonstrates the potential of the MAX phase to enhance both properties and curcumin delivery, promising for other eco-friendly systems for sustainable drug delivery applications.
AB - MXenes, synthesized from their precursor MAX phases, have been extensively researched as additives to enhance the drug delivery performance of polymer matrices, whereas there is a limited number of previous reports on the use of MAX phases themselves for such applications. The use of MAX phases can exclude the complicated synthesis procedure and lessen resultant production and environmental costs required to convert MAX phases to MXenes. Herein, electrospun membranes of poly(lactic acid) (PLA) and a MAX phase (Ti3AlC2) have been fabricated for curcumin delivery. The composite membrane exhibits significantly higher toughness (8.82 MJ m-3) than the plasticized PLA membrane (0.63 MJ m-3) with low cytotoxicity, supporting proliferation of mouse fibroblast L929 cells. The curcumin-loaded composite membrane exhibits high water vapor transmission (~7350 g m-2 day-1), porosity (~85 %), water wettability, and antibacterial properties against E. coli and S. aureus. Seven-day curcumin release is enhanced from 45 % (PLA) to 67 % (composite) due to curcumin diffusion from the polymer fibers and MAX phase surface that contributes to overall increased curcumin adsorption and release sites. This work demonstrates the potential of the MAX phase to enhance both properties and curcumin delivery, promising for other eco-friendly systems for sustainable drug delivery applications.
KW - Poly(lactic acid)
KW - MAX phase
KW - Electrospun membrane
KW - Drug delivery
KW - Curcumin
KW - Low cytotoxicity
UR - https://www.sciencedirect.com/science/article/pii/S0141813024007700?via%3Dihub
UR - http://www.scopus.com/inward/record.url?scp=85184297104&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2024.129967
DO - 10.1016/j.ijbiomac.2024.129967
M3 - Article
SN - 0141-8130
VL - 262
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
M1 - 129967
ER -