Macroporous hydrogels for biomedical applications: methodology and morphology

Brian Tighe, H.R. Oxley, P.H. Corkhill

Research output: Contribution to journalArticle

Abstract

Macroporous hydrogel membranes have been fabricated using two complementary techniques, both involving the polymerization of a solution of monomers around a crystalline matrix which is subsequently removed. The first of these is the freeze-thaw technique, in which aqueous systems are used to form ice-based crystalline matrices. Whereas in the second, the porosigen technique, a crystalline compound (e.g. sucrose) is dispersed in the monomer solution prior to polymerization. Both copolymer composition and the polymerization conditions were found to influence membrane morphology and the limitations in the range of morphologies attainable using each technique are discussed. Careful choice of technique and polymerization conditions enables macroporous hydrogels with a wide range of morphologies to be fabricated, which are potentially valuable in a variety of biomedical applications. The suitability of these techniques described for the production of materials for use in affinity chromatography, as cell separation substrates and as synthetic articular cartilage as well as more general areas of biomedicine, is discussed.
Original languageEnglish
Article numbern/a
Pages (from-to)1064-1072
Number of pages9
JournalBiomaterials
Volume14
Issue number14
DOIs
Publication statusPublished - Nov 1993

Fingerprint

Hydrogels
Polymerization
Crystalline materials
Monomers
Membranes
Affinity chromatography
Cell Separation
Hydrogel
Ice
Cartilage
Sugar (sucrose)
Articular Cartilage
Affinity Chromatography
Sucrose
Copolymers
Substrates
Chemical analysis

Keywords

  • Hydrogels
  • membranes
  • polymerization
  • porosity

Cite this

Tighe, Brian ; Oxley, H.R. ; Corkhill, P.H. / Macroporous hydrogels for biomedical applications : methodology and morphology. In: Biomaterials. 1993 ; Vol. 14, No. 14. pp. 1064-1072.
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Macroporous hydrogels for biomedical applications : methodology and morphology. / Tighe, Brian; Oxley, H.R.; Corkhill, P.H.

In: Biomaterials, Vol. 14, No. 14, n/a, 11.1993, p. 1064-1072.

Research output: Contribution to journalArticle

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T1 - Macroporous hydrogels for biomedical applications

T2 - methodology and morphology

AU - Tighe, Brian

AU - Oxley, H.R.

AU - Corkhill, P.H.

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