Mathematical and computational models for bone tissue engineering in bioreactor systems

Iva Burova, Ivan Wall, Rebecca J Shipley

Research output: Contribution to journalArticle

Abstract

Research into cellular engineered bone grafts offers a promising solution to problems associated with the currently used auto- and allografts. Bioreactor systems can facilitate the development of functional cellular bone grafts by augmenting mass transport through media convection and shear flow-induced mechanical stimulation. Developing successful and reproducible protocols for growing bone tissue in vitro is dependent on tuning the bioreactor operating conditions to the specific cell type and graft design. This process, largely reliant on a trial-and-error approach, is challenging, time-consuming and expensive. Modelling can streamline the process by providing further insight into the effect of the bioreactor environment on the cell culture, and by identifying a beneficial range of operational settings to stimulate tissue production. Models can explore the impact of changing flow speeds, scaffold properties, and nutrient and growth factor concentrations. Aiming to act as an introductory reference for bone tissue engineers looking to direct their experimental work, this article presents a comprehensive framework of mathematical models on various aspects of bioreactor bone cultures and overviews modelling case studies from literature.
Original languageEnglish
Pages (from-to)1-25
JournalJournal of Tissue Engineering
Volume10
Early online date22 Feb 2019
DOIs
Publication statusPublished - 6 Mar 2019

Fingerprint

Bioreactors
Tissue Engineering
Tissue engineering
Bone
Theoretical Models
Bone and Bones
Grafts
Tissue
Transplants
Convection
Autografts
Scaffolds (biology)
Shear flow
Cell culture
Nutrients
Allografts
Intercellular Signaling Peptides and Proteins
Mass transfer
Cell Culture Techniques
Tuning

Bibliographical note

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Keywords

  • Mathematical modelling
  • bioreactors
  • bone tissue engineering
  • parameterisation

Cite this

Burova, Iva ; Wall, Ivan ; Shipley, Rebecca J. / Mathematical and computational models for bone tissue engineering in bioreactor systems. In: Journal of Tissue Engineering. 2019 ; Vol. 10. pp. 1-25.
@article{3c5aec9bd1084f50b9a2e27e6b815cae,
title = "Mathematical and computational models for bone tissue engineering in bioreactor systems",
abstract = "Research into cellular engineered bone grafts offers a promising solution to problems associated with the currently used auto- and allografts. Bioreactor systems can facilitate the development of functional cellular bone grafts by augmenting mass transport through media convection and shear flow-induced mechanical stimulation. Developing successful and reproducible protocols for growing bone tissue in vitro is dependent on tuning the bioreactor operating conditions to the specific cell type and graft design. This process, largely reliant on a trial-and-error approach, is challenging, time-consuming and expensive. Modelling can streamline the process by providing further insight into the effect of the bioreactor environment on the cell culture, and by identifying a beneficial range of operational settings to stimulate tissue production. Models can explore the impact of changing flow speeds, scaffold properties, and nutrient and growth factor concentrations. Aiming to act as an introductory reference for bone tissue engineers looking to direct their experimental work, this article presents a comprehensive framework of mathematical models on various aspects of bioreactor bone cultures and overviews modelling case studies from literature.",
keywords = "Mathematical modelling, bioreactors, bone tissue engineering, parameterisation",
author = "Iva Burova and Ivan Wall and Shipley, {Rebecca J}",
note = "This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).",
year = "2019",
month = "3",
day = "6",
doi = "10.1177/2041731419827922",
language = "English",
volume = "10",
pages = "1--25",

}

Mathematical and computational models for bone tissue engineering in bioreactor systems. / Burova, Iva; Wall, Ivan; Shipley, Rebecca J.

In: Journal of Tissue Engineering, Vol. 10, 06.03.2019, p. 1-25.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mathematical and computational models for bone tissue engineering in bioreactor systems

AU - Burova, Iva

AU - Wall, Ivan

AU - Shipley, Rebecca J

N1 - This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PY - 2019/3/6

Y1 - 2019/3/6

N2 - Research into cellular engineered bone grafts offers a promising solution to problems associated with the currently used auto- and allografts. Bioreactor systems can facilitate the development of functional cellular bone grafts by augmenting mass transport through media convection and shear flow-induced mechanical stimulation. Developing successful and reproducible protocols for growing bone tissue in vitro is dependent on tuning the bioreactor operating conditions to the specific cell type and graft design. This process, largely reliant on a trial-and-error approach, is challenging, time-consuming and expensive. Modelling can streamline the process by providing further insight into the effect of the bioreactor environment on the cell culture, and by identifying a beneficial range of operational settings to stimulate tissue production. Models can explore the impact of changing flow speeds, scaffold properties, and nutrient and growth factor concentrations. Aiming to act as an introductory reference for bone tissue engineers looking to direct their experimental work, this article presents a comprehensive framework of mathematical models on various aspects of bioreactor bone cultures and overviews modelling case studies from literature.

AB - Research into cellular engineered bone grafts offers a promising solution to problems associated with the currently used auto- and allografts. Bioreactor systems can facilitate the development of functional cellular bone grafts by augmenting mass transport through media convection and shear flow-induced mechanical stimulation. Developing successful and reproducible protocols for growing bone tissue in vitro is dependent on tuning the bioreactor operating conditions to the specific cell type and graft design. This process, largely reliant on a trial-and-error approach, is challenging, time-consuming and expensive. Modelling can streamline the process by providing further insight into the effect of the bioreactor environment on the cell culture, and by identifying a beneficial range of operational settings to stimulate tissue production. Models can explore the impact of changing flow speeds, scaffold properties, and nutrient and growth factor concentrations. Aiming to act as an introductory reference for bone tissue engineers looking to direct their experimental work, this article presents a comprehensive framework of mathematical models on various aspects of bioreactor bone cultures and overviews modelling case studies from literature.

KW - Mathematical modelling

KW - bioreactors

KW - bone tissue engineering

KW - parameterisation

UR - http://journals.sagepub.com/doi/10.1177/2041731419827922

UR - http://www.scopus.com/inward/record.url?scp=85062063054&partnerID=8YFLogxK

U2 - 10.1177/2041731419827922

DO - 10.1177/2041731419827922

M3 - Article

C2 - 30834100

VL - 10

SP - 1

EP - 25

ER -