Matrix-assisted diffusion-ordered spectroscopy: mixture resolution by NMR using SDSmicelles

Cláudio F. Tormena, Robert Evans, Stephan Haiber, Mathias Nilsson, Gareth A. Morris

Research output: Contribution to journalArticle

Abstract

Diffusion-ordered spectroscopy (DOSY) is a powerful technique for mixture analysis, but in its basic form it cannot separate the component spectra for species with very similar diffusion coefficients. It has been recently demonstrated that the component spectra of a mixture of isomers with nearly identical diffusion coefficients (the three dihydroxybenzenes) can be resolved using matrix-assisted DOSY (MAD), in which diffusion is perturbed by the addition of a co-solute such as a surfactant [R. Evans, S. Haiber, M. Nilsson, G. A. Morris, Anal. Chem. 2009, 81, 4548-4550]. However, little is known about the conditions required for such a separation, for example, the concentrations and concentration ratios of surfactant and solutes. The aim of this study was to explore the concentration range over whichmatrix-assisted DOSY using the surfactant SDS can achieve diffusion resolution of a simple model set of isomers, the monomethoxyphenols. The results show that the separation is remarkably robust with respect to both the concentrations and the concentration ratios of surfactant and solutes, supporting the idea that MAD may become a valuable tool formixture analysis.
LanguageEnglish
Pages550-553
Number of pages4
JournalMagnetic Resonance in Chemistry
Volume48
Issue number7
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Nuclear magnetic resonance
Spectroscopy
Surface-Active Agents
Surface active agents
Isomers

Keywords

  • NMR
  • 1H
  • DOSY
  • surfactant
  • micelle

Cite this

Tormena, Cláudio F. ; Evans, Robert ; Haiber, Stephan ; Nilsson, Mathias ; Morris, Gareth A. / Matrix-assisted diffusion-ordered spectroscopy : mixture resolution by NMR using SDSmicelles. In: Magnetic Resonance in Chemistry. 2010 ; Vol. 48, No. 7. pp. 550-553.
@article{17accd45bf9c43e09e5938c15a88692e,
title = "Matrix-assisted diffusion-ordered spectroscopy: mixture resolution by NMR using SDSmicelles",
abstract = "Diffusion-ordered spectroscopy (DOSY) is a powerful technique for mixture analysis, but in its basic form it cannot separate the component spectra for species with very similar diffusion coefficients. It has been recently demonstrated that the component spectra of a mixture of isomers with nearly identical diffusion coefficients (the three dihydroxybenzenes) can be resolved using matrix-assisted DOSY (MAD), in which diffusion is perturbed by the addition of a co-solute such as a surfactant [R. Evans, S. Haiber, M. Nilsson, G. A. Morris, Anal. Chem. 2009, 81, 4548-4550]. However, little is known about the conditions required for such a separation, for example, the concentrations and concentration ratios of surfactant and solutes. The aim of this study was to explore the concentration range over whichmatrix-assisted DOSY using the surfactant SDS can achieve diffusion resolution of a simple model set of isomers, the monomethoxyphenols. The results show that the separation is remarkably robust with respect to both the concentrations and the concentration ratios of surfactant and solutes, supporting the idea that MAD may become a valuable tool formixture analysis.",
keywords = "NMR, 1H, DOSY, surfactant, micelle",
author = "Tormena, {Cl{\'a}udio F.} and Robert Evans and Stephan Haiber and Mathias Nilsson and Morris, {Gareth A.}",
year = "2010",
month = "7",
doi = "10.1002/mrc.2621",
language = "English",
volume = "48",
pages = "550--553",
journal = "Magnetic Resonance in Chemistry",
issn = "0749-1581",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

Matrix-assisted diffusion-ordered spectroscopy : mixture resolution by NMR using SDSmicelles. / Tormena, Cláudio F.; Evans, Robert; Haiber, Stephan; Nilsson, Mathias; Morris, Gareth A.

In: Magnetic Resonance in Chemistry, Vol. 48, No. 7, 07.2010, p. 550-553.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Matrix-assisted diffusion-ordered spectroscopy

T2 - Magnetic Resonance in Chemistry

AU - Tormena, Cláudio F.

AU - Evans, Robert

AU - Haiber, Stephan

AU - Nilsson, Mathias

AU - Morris, Gareth A.

PY - 2010/7

Y1 - 2010/7

N2 - Diffusion-ordered spectroscopy (DOSY) is a powerful technique for mixture analysis, but in its basic form it cannot separate the component spectra for species with very similar diffusion coefficients. It has been recently demonstrated that the component spectra of a mixture of isomers with nearly identical diffusion coefficients (the three dihydroxybenzenes) can be resolved using matrix-assisted DOSY (MAD), in which diffusion is perturbed by the addition of a co-solute such as a surfactant [R. Evans, S. Haiber, M. Nilsson, G. A. Morris, Anal. Chem. 2009, 81, 4548-4550]. However, little is known about the conditions required for such a separation, for example, the concentrations and concentration ratios of surfactant and solutes. The aim of this study was to explore the concentration range over whichmatrix-assisted DOSY using the surfactant SDS can achieve diffusion resolution of a simple model set of isomers, the monomethoxyphenols. The results show that the separation is remarkably robust with respect to both the concentrations and the concentration ratios of surfactant and solutes, supporting the idea that MAD may become a valuable tool formixture analysis.

AB - Diffusion-ordered spectroscopy (DOSY) is a powerful technique for mixture analysis, but in its basic form it cannot separate the component spectra for species with very similar diffusion coefficients. It has been recently demonstrated that the component spectra of a mixture of isomers with nearly identical diffusion coefficients (the three dihydroxybenzenes) can be resolved using matrix-assisted DOSY (MAD), in which diffusion is perturbed by the addition of a co-solute such as a surfactant [R. Evans, S. Haiber, M. Nilsson, G. A. Morris, Anal. Chem. 2009, 81, 4548-4550]. However, little is known about the conditions required for such a separation, for example, the concentrations and concentration ratios of surfactant and solutes. The aim of this study was to explore the concentration range over whichmatrix-assisted DOSY using the surfactant SDS can achieve diffusion resolution of a simple model set of isomers, the monomethoxyphenols. The results show that the separation is remarkably robust with respect to both the concentrations and the concentration ratios of surfactant and solutes, supporting the idea that MAD may become a valuable tool formixture analysis.

KW - NMR

KW - 1H

KW - DOSY

KW - surfactant

KW - micelle

UR - http://www.scopus.com/inward/record.url?scp=77953946453&partnerID=8YFLogxK

UR - http://onlinelibrary.wiley.com/doi/10.1002/mrc.2621/abstract

U2 - 10.1002/mrc.2621

DO - 10.1002/mrc.2621

M3 - Article

VL - 48

SP - 550

EP - 553

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

SN - 0749-1581

IS - 7

ER -