Abstract
The feasibility of using a small-scale avalanche tester to measure the flow properties of pharmaceutical lactose powders was examined. The modes of behaviour observed in larger systems were displayed and showed a clear distinction between angular, free-flowing particles and more spherical particles of similar flow characteristics. Angular Lactohale LH100 particles showed slumping behaviour at a rotational frequency of 0.33Hz which disappeared at higher frequencies. Spherical lactose powder with a similar flow function to LH100 only showed rolling behaviour under the same conditions, as did more cohesive powders LH200 and LH300. Further investigation of the LH100 data using Fast Fourier analysis showed that the slumping frequency was 1/10th of the rotational frequency.
| Original language | English |
|---|---|
| Pages (from-to) | 723-728 |
| Number of pages | 6 |
| Journal | Drying Technology |
| Volume | 34 |
| Issue number | 6 |
| Early online date | 27 Jul 2015 |
| DOIs | |
| Publication status | E-pub ahead of print - 27 Jul 2015 |
Bibliographical note
This is an Accepted Manuscript of an article published by Taylor & Francis in Drying Technology on 27/7/15, available online: http://www.tandfonline.com/10.1080/07373937.2015.1072093Keywords
- pharmaceuticals
- powder technology
- rotary drying