Mechanisms of action of microbicides

Peter A. Lambert*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

This chapter describes the sites and mechanisms of action of the major groups of microbicides, relating their physical and chemical properties to interactions with microbial structures. It considers the physical, cellular and molecular methods for studying the mechanisms of action of chemical microbicides. These range from the uptake, binding and penetration of microbial cells, to the interaction with microbial structures, including the cell wall, membrane, nucleic acids, cytoplasm and enzymes. Key features of the mechanisms of action of the major groups of microbicides are described covering oxidizing agents, alkylating agents, metal ion-binding agents, nucleic acid-binding agents, protein denaturants and agents that interact with lipids.

Original languageEnglish
Title of host publicationRussell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization
EditorsAdam P. Fraise, Jean-Yves Maillard, Syed Sattar
Place of PublicationChirchester (UK)
PublisherWiley-Blackwell
Pages95-107
Number of pages13
Edition5th
ISBN (Electronic)978-1-118-42586-2
ISBN (Print)978-1-4443-3325-1
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Anti-Infective Agents
Nucleic Acids
Microbial Interactions
Pharmacologic Actions
Alkylating Agents
Oxidants
Cell Communication
Cell Wall
Carrier Proteins
Cytoplasm
Metals
Cell Membrane
Ions
Lipids
Enzymes

Keywords

  • alkylating agents
  • antimicrobial action
  • mechanism of action
  • metal ion-binding agents
  • microbicide
  • mode of action
  • nucleic acid-binding agents
  • oxidizing agents
  • protein denaturants
  • target site

Cite this

Lambert, P. A. (2012). Mechanisms of action of microbicides. In A. P. Fraise, J-Y. Maillard, & S. Sattar (Eds.), Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization (5th ed., pp. 95-107). Chirchester (UK): Wiley-Blackwell. https://doi.org/10.1002/9781118425831.ch5
Lambert, Peter A. / Mechanisms of action of microbicides. Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization. editor / Adam P. Fraise ; Jean-Yves Maillard ; Syed Sattar. 5th. ed. Chirchester (UK) : Wiley-Blackwell, 2012. pp. 95-107
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Lambert, PA 2012, Mechanisms of action of microbicides. in AP Fraise, J-Y Maillard & S Sattar (eds), Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization. 5th edn, Wiley-Blackwell, Chirchester (UK), pp. 95-107. https://doi.org/10.1002/9781118425831.ch5

Mechanisms of action of microbicides. / Lambert, Peter A.

Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization. ed. / Adam P. Fraise; Jean-Yves Maillard; Syed Sattar. 5th. ed. Chirchester (UK) : Wiley-Blackwell, 2012. p. 95-107.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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Lambert PA. Mechanisms of action of microbicides. In Fraise AP, Maillard J-Y, Sattar S, editors, Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization. 5th ed. Chirchester (UK): Wiley-Blackwell. 2012. p. 95-107 https://doi.org/10.1002/9781118425831.ch5