Mechanisms of action of microbicides

Peter A. Lambert*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

This chapter describes the sites and mechanisms of action of the major groups of microbicides, relating their physical and chemical properties to interactions with microbial structures. It considers the physical, cellular and molecular methods for studying the mechanisms of action of chemical microbicides. These range from the uptake, binding and penetration of microbial cells, to the interaction with microbial structures, including the cell wall, membrane, nucleic acids, cytoplasm and enzymes. Key features of the mechanisms of action of the major groups of microbicides are described covering oxidizing agents, alkylating agents, metal ion-binding agents, nucleic acid-binding agents, protein denaturants and agents that interact with lipids.

Original languageEnglish
Title of host publicationRussell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization
EditorsAdam P. Fraise, Jean-Yves Maillard, Syed Sattar
Place of PublicationChirchester (UK)
PublisherWiley-Blackwell
Pages95-107
Number of pages13
Edition5th
ISBN (Electronic)978-1-118-42586-2
ISBN (Print)978-1-4443-3325-1
DOIs
Publication statusPublished - Nov 2012

Keywords

  • alkylating agents
  • antimicrobial action
  • mechanism of action
  • metal ion-binding agents
  • microbicide
  • mode of action
  • nucleic acid-binding agents
  • oxidizing agents
  • protein denaturants
  • target site

Fingerprint Dive into the research topics of 'Mechanisms of action of microbicides'. Together they form a unique fingerprint.

  • Research Output

    • 1 Chapter (peer-reviewed)

    Radiation sterilization

    Lambert, P. A., Nov 2012, Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization. Fraise, A. P., Maillard, J-Y. & Sattar, S. (eds.). 5th ed. Chirchester (UK): Wiley-Blackwell, p. 294-305 12 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    Cite this

    Lambert, P. A. (2012). Mechanisms of action of microbicides. In A. P. Fraise, J-Y. Maillard, & S. Sattar (Eds.), Russell, Hugo and Ayliffe's principles and practice of disinfection, preservation and sterilization (5th ed., pp. 95-107). Wiley-Blackwell. https://doi.org/10.1002/9781118425831.ch5