Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen

Oxana Semyachkina-Glushkovskaya, Denis Bragin, Ivan Fedosov, Inna Blokhina, Alexander Khorovodov, Andrey Terskov, Alexander Shirokov, Alexander Dubrovsky, Valeria Vinnik, Arina Evsukova, Daria Elovenko, Viktoria Adushkina, Maria Tzoy, Alexander Dmitrenko, Valeria Krupnova, Maria Manzhaeva, Ilana Agranovich, Elena Saranceva, Tatyana Iskra, Ekaterina LykovaSergey Sokolovski, Edik Rafailov, Jürgen Kurths

Research output: Chapter in Book/Published conference outputConference publication


There is strong evidence that augmentation of the brain's waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain's waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain's waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain's waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.

Original languageEnglish
Title of host publicationOxygen Transport to Tissue XLIV. ISOTT 2022
EditorsF. Scholkmann, J. LaManna, U. Wolf
Number of pages6
ISBN (Electronic)978-3-031-42003-0
ISBN (Print)978-3-031-42002-3
Publication statusPublished - 17 Oct 2023

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Meningeal lymphatics
  • Brain - physiology
  • Brain’s waste disposal system
  • Photostimulation
  • Reactive Oxygen Species
  • Meninges
  • Singlet oxygen
  • Singlet Oxygen
  • Nitric Oxide


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