TY - GEN
T1 - Mechanisms of Photostimulation of Brain's Waste Disposal System
T2 - The Role of Singlet Oxygen
AU - Semyachkina-Glushkovskaya, Oxana
AU - Bragin, Denis
AU - Fedosov, Ivan
AU - Blokhina, Inna
AU - Khorovodov, Alexander
AU - Terskov, Andrey
AU - Shirokov, Alexander
AU - Dubrovsky, Alexander
AU - Vinnik, Valeria
AU - Evsukova, Arina
AU - Elovenko, Daria
AU - Adushkina, Viktoria
AU - Tzoy, Maria
AU - Dmitrenko, Alexander
AU - Krupnova, Valeria
AU - Manzhaeva, Maria
AU - Agranovich, Ilana
AU - Saranceva, Elena
AU - Iskra, Tatyana
AU - Lykova, Ekaterina
AU - Sokolovski, Sergey
AU - Rafailov, Edik
AU - Kurths, Jürgen
PY - 2023/10/17
Y1 - 2023/10/17
N2 - There is strong evidence that augmentation of the brain's waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain's waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain's waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain's waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.
AB - There is strong evidence that augmentation of the brain's waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain's waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain's waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain's waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.
KW - Meningeal lymphatics
KW - Brain - physiology
KW - Brain’s waste disposal system
KW - Photostimulation
KW - Reactive Oxygen Species
KW - Meninges
KW - Singlet oxygen
KW - Singlet Oxygen
KW - Nitric Oxide
UR - http://www.scopus.com/inward/record.url?scp=85174749955&partnerID=8YFLogxK
UR - https://link.springer.com/chapter/10.1007/978-3-031-42003-0_8
U2 - 10.1007/978-3-031-42003-0_8
DO - 10.1007/978-3-031-42003-0_8
M3 - Conference publication
C2 - 37845438
SN - 978-3-031-42002-3
VL - 1438
T3 - Advances in Experimental Medicine and Biology
SP - 45
EP - 50
BT - Oxygen Transport to Tissue XLIV. ISOTT 2022
A2 - Scholkmann, F.
A2 - LaManna, J.
A2 - Wolf, U.
PB - Springer
ER -