MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery

Elaine Foley, J. Helen Cross, Ngoc J. Thai, A. Richard Walsh, Peter Bill, Paul Furlong, Amanda G. Wood, Antonella Cerquiglini, Stefano Seri

Research output: Contribution to journalArticle

Abstract

Establishing language dominance is an important step in the presurgical evaluation of patients with refractory epilepsy. In the absence of a universally accepted gold-standard non-invasive method to determine language dominance in the preoperative assessment, a range of tools and methodologies have recently received attention. When applied to pediatric age, many of the proposed methods, such as functional magnetic resonance imaging (fMRI), may present some challenges due to the time-varying effects of epileptogenic lesions and of on-going seizures on maturational phenomena. Magnetoencephalography (MEG) has the advantage of being insensitive to the distortive effects of anatomical lesions on brain microvasculature and to differences in the metabolism or vascularization of the developing brain and also provides a less intimidating recording environment for younger children. In this study we investigated the reliability of lateralized synchronous cortical activation during a verb generation task in a group of 28 children (10 males and 18 females, mean age 12 years) with refractory epilepsy who were evaluated for epilepsy surgery. The verb generation task was associated with significant decreases in beta oscillatory power (13–30 Hz) in frontal and temporal lobes. The MEG data were compared with other available presurgical non-invasive data including cortical stimulation, neuropsychological and fMRI data on language lateralization where available. We found that the lateralization of MEG beta power reduction was concordant with language dominance determined by one or more different assessment methods (i.e. cortical stimulation mapping, neuropsychological, fMRI or post-operative data) in 89% of patients. Our data suggest that qualitative hemispheric differences in task-related changes of spectral power could offer a promising insight into the contribution of dominant and non-dominant hemispheres in language processing and may help to characterize the specialization and lateralization of language processes in children.
Original languageEnglish
Pages (from-to)492-503
Number of pages12
JournalBrain Topography
Volume32
Issue number3
Early online date20 Mar 2019
DOIs
Publication statusPublished - 1 May 2019

Fingerprint

Magnetoencephalography
Child Language
Epilepsy
Language
Magnetic Resonance Imaging
Brain
Frontal Lobe
Temporal Lobe
Microvessels
Gold
Seizures
Pediatrics
Power (Psychology)

Bibliographical note

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

  • Beamformers
  • Children
  • Epilepsy surgery
  • Functional mapping
  • Hemispheric dominance
  • Language lateralization
  • Magnetoencephalography

Cite this

Foley, Elaine ; Cross, J. Helen ; Thai, Ngoc J. ; Walsh, A. Richard ; Bill, Peter ; Furlong, Paul ; Wood, Amanda G. ; Cerquiglini, Antonella ; Seri, Stefano. / MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery. In: Brain Topography. 2019 ; Vol. 32, No. 3. pp. 492-503.
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MEG Assessment of Expressive Language in Children Evaluated for Epilepsy Surgery. / Foley, Elaine; Cross, J. Helen; Thai, Ngoc J.; Walsh, A. Richard; Bill, Peter; Furlong, Paul; Wood, Amanda G.; Cerquiglini, Antonella; Seri, Stefano.

In: Brain Topography, Vol. 32, No. 3, 01.05.2019, p. 492-503.

Research output: Contribution to journalArticle

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AU - Wood, Amanda G.

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