Metabolic and morphological evaluation of an artificial full-thickness skin model using a multimodal photonic system

Arooj Khalid*, Viktor Dremin, Ayman El-Tamer, Maria Surnina, Celine Lancelot, Edik Rafailov, Sergei Sokolovski

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


The fabrication of artificial tissue and organ models is one of the important directions of the development of modern biomedicine. Assessment of the morphology, maturation, and viability is an important part of such developments. Here, we report on the validation of our custom-build fluorescence spectroscopy (FS) system with optical coherence tomography (OCT) for assessing the metabolism and morphology of the full-thickness skin equivalence (FSE) model. FS along with OCT has been used for the metabolic activity evaluation of the developed FSE model and 3D imaging of its structure. Thus, we have developed a multimodal optical system that can be used in the future for a full-profile assessment of the maturation and viability of 3D-printed models of biological tissues in time-course development.

Original languageEnglish
Article number126290T
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 11 Aug 2023
EventEmerging Technologies for Cell and Tissue Characterization II 2023 - Munich, Germany
Duration: 28 Jun 202329 Jun 2023

Bibliographical note

Funding Information:
This work was supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 951890 (PLATFORMA project).

Copyright 2023 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.


  • artificial full-thickness skin model
  • fibroblasts
  • fluorescence spectroscopy
  • keratinocytes
  • optical coherence tomography
  • scaffolds


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