MHCPred : a server for quantitative prediction of peptide-MHC binding

Pingping Guan, Irini A. Doytchinova, Christianna Zygouri, Darren R. Flower

Research output: Contribution to journalArticle

Abstract

Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at
large, we have implemented, as a server on the World Wide Web, a partial least squares-base multivariate statistical approach to the quantitative prediction of peptide binding to major histocom-patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive,cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203,HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401and HLA-DRB* 0701).
Original languageEnglish
Pages (from-to)3621-3624
Number of pages4
JournalNucleic Acids Research
Volume31
Issue number13
DOIs
Publication statusPublished - Jul 2003

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HLA-A Antigens
Peptides
Dichlororibofuranosylbenzimidazole
Alleles
T-Lymphocyte Epitopes
HLA-B Antigens
Antigen Presentation
Adaptive Immunity
Statistical Models
Allergy and Immunology
Least-Squares Analysis
Cellular Immunity
Internet

Cite this

Guan, P., Doytchinova, I. A., Zygouri, C., & Flower, D. R. (2003). MHCPred : a server for quantitative prediction of peptide-MHC binding. Nucleic Acids Research, 31(13), 3621-3624. https://doi.org/10.1093/nar/gkg510
Guan, Pingping ; Doytchinova, Irini A. ; Zygouri, Christianna ; Flower, Darren R. / MHCPred : a server for quantitative prediction of peptide-MHC binding. In: Nucleic Acids Research. 2003 ; Vol. 31, No. 13. pp. 3621-3624.
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Guan, P, Doytchinova, IA, Zygouri, C & Flower, DR 2003, 'MHCPred : a server for quantitative prediction of peptide-MHC binding', Nucleic Acids Research, vol. 31, no. 13, pp. 3621-3624. https://doi.org/10.1093/nar/gkg510

MHCPred : a server for quantitative prediction of peptide-MHC binding. / Guan, Pingping; Doytchinova, Irini A.; Zygouri, Christianna; Flower, Darren R.

In: Nucleic Acids Research, Vol. 31, No. 13, 07.2003, p. 3621-3624.

Research output: Contribution to journalArticle

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