Multifunctional bioactive glass scaffolds coated with layers of poly(d,l-lactide-co-glycolide) and poly(n-isopropylacrylamide-co-acrylic acid) microgels loaded with vancomycin

B. Olalde, N. Garmendia, V. Sáez-Martínez, N. Argarate, P. Nooeaid, F. Morin, A.R. Boccaccini

Research output: Contribution to journalArticle

Abstract

A new family of multifunctional scaffolds, incorporating selected biopolymer coatings on basic Bioglass® derived foams has been developed. The polymer coatings were investigated as carrier of vancomycin which is a suitable drug to impart antibiotic function to the scaffolds. It has been proved that coating with PLGA (poly(lactic-co-glycolic acid)) with dispersed vancomycin-loaded microgels provides a rapid delivery of drug to give antibacterial effects at the wound site and a further sustained release to aid mid to long-term healing. Furthermore, the microgels also improved the bioactivity of the scaffolds by acting as nucleation sites for the formation of HA crystals in simulated body fluid.
Original languageEnglish
Pages (from-to)3760-3767
Number of pages8
JournalMaterials Science and Engineering C
Volume33
Issue number7
DOIs
Publication statusPublished - Oct 2013

Keywords

  • scaffold
  • Bioglass®
  • vancomycin
  • microgel
  • PLGA
  • drug delivery

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