Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

Filipe v. Ferreira; Alana g. Souza; Rubina Ajdary; Lucas p. De souza; João h. Lopes; Daniel s. Correa; Gilberto Siqueira; Hernane s. Barud; Derval dos s. Rosa; Luiz h.c. Mattoso; Orlando j. Rojas

doi:10.1016/j.bioactmat.2023.06.020

Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

Filipe v. Ferreira, Alana g. Souza, Rubina Ajdary, Lucas p. De souza, João h. Lopes, Daniel s. Correa, Gilberto Siqueira, Hernane s. Barud, Derval dos s. Rosa, Luiz h.c. Mattoso^*, Orlando j. Rojas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure–property–function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

Original language	English
Pages (from-to)	151-176
Number of pages	25
Journal	Bioactive Materials
Volume	29
Early online date	12 Jul 2023
DOIs	https://doi.org/10.1016/j.bioactmat.2023.06.020
Publication status	Published - 1 Nov 2023

Bibliographical note

Funding: The authors acknowledge the financial support from the Sao ˜ Paulo
Research Foundation [FAPESP; Grants No. 2016/10636-8, 2020/07956-
6, 2018/22214-6, 2022/03247-6], the Brazilian National Council for
Scientific and Technological Development [CNPq; ; Grants No 001], the
European Research Council (ERC) under the European Union’s Horizon
2020 research and innovation program [ERC Advanced Grant Agreement No. 788489, “BioElCell”], the Canada Excellence Research Chair
Program [CERC-2018-00006], and Canada Foundation for Innovation
[Project number 38623].
Copyright © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY
license (http://creativecommons.org/licenses/by/4.0/).

Keywords

cellulose nanofibrils
cellulose nanocrystals
regenerative medicine
biomaterial
sustainable materials
green nanomaterials

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10.1016/j.bioactmat.2023.06.020Licence: CC BY 4.0

nanocellulose-based porous materials
Copyright © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 12.4 MBLicence: CC BY 4.0

https://linkinghub.elsevier.com/retrieve/pii/S2452199X23002037

Cite this

@article{fc3910824e5341f4824cd6bd44b337d0,

title = "Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine",

abstract = "We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure–property–function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed. ",

keywords = "cellulose nanofibrils, cellulose nanocrystals, regenerative medicine, biomaterial, sustainable materials, green nanomaterials",

author = "Ferreira, {Filipe v.} and Souza, {Alana g.} and Rubina Ajdary and {De souza}, {Lucas p.} and Lopes, {Jo{\~a}o h.} and Correa, {Daniel s.} and Gilberto Siqueira and Barud, {Hernane s.} and Rosa, {Derval dos s.} and Mattoso, {Luiz h.c.} and Rojas, {Orlando j.}",

note = "Funding: The authors acknowledge the financial support from the Sao ˜ Paulo Research Foundation [FAPESP; Grants No. 2016/10636-8, 2020/07956- 6, 2018/22214-6, 2022/03247-6], the Brazilian National Council for Scientific and Technological Development [CNPq; ; Grants No 001], the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation program [ERC Advanced Grant Agreement No. 788489, “BioElCell”], the Canada Excellence Research Chair Program [CERC-2018-00006], and Canada Foundation for Innovation [Project number 38623]. Copyright {\textcopyright} 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ",

year = "2023",

month = nov,

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doi = "10.1016/j.bioactmat.2023.06.020",

language = "English",

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AU - Ferreira, Filipe v.

AU - Souza, Alana g.

AU - Ajdary, Rubina

AU - De souza, Lucas p.

AU - Lopes, João h.

AU - Correa, Daniel s.

AU - Siqueira, Gilberto

AU - Barud, Hernane s.

AU - Rosa, Derval dos s.

AU - Mattoso, Luiz h.c.

AU - Rojas, Orlando j.

N1 - Funding: The authors acknowledge the financial support from the Sao ˜ Paulo Research Foundation [FAPESP; Grants No. 2016/10636-8, 2020/07956- 6, 2018/22214-6, 2022/03247-6], the Brazilian National Council for Scientific and Technological Development [CNPq; ; Grants No 001], the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program [ERC Advanced Grant Agreement No. 788489, “BioElCell”], the Canada Excellence Research Chair Program [CERC-2018-00006], and Canada Foundation for Innovation [Project number 38623]. Copyright © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PY - 2023/11/1

Y1 - 2023/11/1

N2 - We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure–property–function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

AB - We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure–property–function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

KW - cellulose nanofibrils

KW - cellulose nanocrystals

KW - regenerative medicine

KW - biomaterial

KW - sustainable materials

KW - green nanomaterials

UR - https://www.sciencedirect.com/science/article/pii/S2452199X23002037

U2 - 10.1016/j.bioactmat.2023.06.020

DO - 10.1016/j.bioactmat.2023.06.020

M3 - Article

SN - 2452-199X

VL - 29

SP - 151

EP - 176

JO - Bioactive Materials

JF - Bioactive Materials

ER -

Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

Abstract

Bibliographical note

Keywords

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