Neurophysiology of CSWS-associated cognitive dysfunction

Stefano Seri, Jade N. Thai, Daniela Brazzo, Francesco Pisani, Antonella Cerquiglini

Research output: Contribution to journalArticle

Abstract

The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.
LanguageEnglish
Pages33-36
Number of pages4
JournalEpilepsia
Volume50
Issue numberSuppl. 7
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Neurophysiology
Landau-Kleffner Syndrome
Phenotype
Myoclonus
Sleep
Cognitive Dysfunction

Keywords

  • Landau-Kleffner syndrome
  • CSWS
  • Magnetoencephalography
  • EEG-triggered fMRI
  • auditory sensory processing

Cite this

Seri, S., Thai, J. N., Brazzo, D., Pisani, F., & Cerquiglini, A. (2009). Neurophysiology of CSWS-associated cognitive dysfunction. Epilepsia, 50(Suppl. 7), 33-36. https://doi.org/10.1111/j.1528-1167.2009.02216.x
Seri, Stefano ; Thai, Jade N. ; Brazzo, Daniela ; Pisani, Francesco ; Cerquiglini, Antonella. / Neurophysiology of CSWS-associated cognitive dysfunction. In: Epilepsia. 2009 ; Vol. 50, No. Suppl. 7. pp. 33-36.
@article{bdf0f11a023a4ca9a9dd35d1b3fced4c,
title = "Neurophysiology of CSWS-associated cognitive dysfunction",
abstract = "The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can {"}per se{"} produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.",
keywords = "Landau-Kleffner syndrome, CSWS, Magnetoencephalography, EEG-triggered fMRI, auditory sensory processing",
author = "Stefano Seri and Thai, {Jade N.} and Daniela Brazzo and Francesco Pisani and Antonella Cerquiglini",
year = "2009",
month = "8",
doi = "10.1111/j.1528-1167.2009.02216.x",
language = "English",
volume = "50",
pages = "33--36",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley",
number = "Suppl. 7",

}

Seri, S, Thai, JN, Brazzo, D, Pisani, F & Cerquiglini, A 2009, 'Neurophysiology of CSWS-associated cognitive dysfunction' Epilepsia, vol. 50, no. Suppl. 7, pp. 33-36. https://doi.org/10.1111/j.1528-1167.2009.02216.x

Neurophysiology of CSWS-associated cognitive dysfunction. / Seri, Stefano; Thai, Jade N.; Brazzo, Daniela; Pisani, Francesco; Cerquiglini, Antonella.

In: Epilepsia, Vol. 50, No. Suppl. 7, 08.2009, p. 33-36.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neurophysiology of CSWS-associated cognitive dysfunction

AU - Seri, Stefano

AU - Thai, Jade N.

AU - Brazzo, Daniela

AU - Pisani, Francesco

AU - Cerquiglini, Antonella

PY - 2009/8

Y1 - 2009/8

N2 - The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.

AB - The phenomenon of continuous spikes and waves during slow-wave sleep (CSWS) is associated with a number of epileptic syndromes, which share a behavioral phenotype characterized by deterioration of cognitive, behavioral, or sensorimotor functions. Available evidence seems to suggest that spike-wave activity is a result of a complex interaction between cortical and subcortical inhibitory networks and can "per se" produce a transient loss of underlying cortical functions. Syndromes like Landau-Kleffner syndrome, CSWS, and phenomena such as negative myoclonus could share in common--at least at the neurophysiological level--some similarities. Differences in behavioral phenotypes could be explained in term of maturational and genetic differences, as well as by the functional specificity of the involved areas.

KW - Landau-Kleffner syndrome

KW - CSWS

KW - Magnetoencephalography

KW - EEG-triggered fMRI

KW - auditory sensory processing

UR - http://www.scopus.com/inward/record.url?scp=68149125588&partnerID=8YFLogxK

UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02216.x/abstract

U2 - 10.1111/j.1528-1167.2009.02216.x

DO - 10.1111/j.1528-1167.2009.02216.x

M3 - Article

VL - 50

SP - 33

EP - 36

JO - Epilepsia

T2 - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - Suppl. 7

ER -