Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19

Julie Davies, Harpal S. Randeva, Kamaljit Chatha, Marcia Hall, Demetrios A. Spandidos, Emmanouil Karteris*, Ioannis Kyrou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the cause of the new viral infectious disease (coronavirus disease 2019; COVID-19). Emerging evidence indicates that COVID-19 may be associated with a wide spectrum of neurological symptoms and complications with central nervous system (CNS) involvement. It is now well-established that entry of SARS-CoV-2 into host cells is facilitated by its spike proteins mainly through binding to the angiotensin-converting enzyme 2 (ACE-2). Preclinical studies have suggested that neuropilin-1 (NRP1), which is a transmembrane receptor that lacks a cytosolic protein kinase domain and exhibits high expression in the respiratory and olfactory epithelium, may also be implicated in COVID-19 by enhancing the entry of SARS-CoV-2 into the brain through the olfactory epithelium. In the present study, we expand on these findings and demonstrate that the NRP1 is also expressed in the CNS, including olfactory-related regions such as the olfactory tubercles and paraolfactory gyri. This furthers supports the potential role of NRP1 as an additional SARS-CoV-2 infection mediator implicated in the neurologic manifestations of COVID-19. Accordingly, the neurotropism of SARS-CoV-2 via NRP1-expressing cells in the CNS merits further investigation.

Original languageEnglish
Pages (from-to)4221-4226
Number of pages6
JournalMolecular Medicine Reports
Volume22
Issue number5
Early online date15 Sep 2020
DOIs
Publication statusPublished - 1 Nov 2020

Bibliographical note

© Davies et al. This work is licensed under a Creative Commons
Attribution-NonCommercial-NoDerivatives 4.0
International (CC BY-NC-ND 4.0) License

Keywords

  • Brain
  • Central nervous system
  • COVID-19
  • Neurologic symptoms
  • Neuropilin-1
  • Neurotropism
  • SARS-CoV-2

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