Objective clinical performance of ‘comfort-enhanced' daily disposable soft contact lenses

James S Wolffsohn, Olivia A Hunt, Ashock Chowdhury

Research output: Contribution to journalArticlepeer-review


Purpose: To examine the objective clinical performance of ‘comfort-enhanced’ daily disposable contact lenses over a 16-h day.
Methods: Four contact lenses (Hilafilcon B, Etafilcon A Plus, Nelfilcon A and Nelfilcon A Plus) were evaluated in an investigator masked, open label trial at the end of a week’s bilateral wear. Pre-lens noninvasive tear break-up time (PL-NITBUT), tear prism height, bulbar hyperaemia and ocular surface temperature (OST) were measured with the lens in situ at 8, 12 and 16 h of wear.
Results: There was no difference between how many hours the lenses types were worn each day (F = 0.90, p = 0.44). The PL-NITBUT decreased with the duration of daily lens wear (F = 32.0, p < 0.001) and was more stable with Nelfilcon A Plus (F = 6.00, p = 0.002) than with the other lenses evaluated.
Bulbar blood vessels increased in coverage (F = 11.5, p < 0.001) but not overall redness (F = 0.0, p = 0.99) with the duration of daily lens wear, but there was no difference between the lenses (p > 0.05). The tear prism height decreased with the duration of daily wear (F = 27.0, p < 0.001) and differed between lenses (F = 2.9, p = 0.04). The OST decreased with the duration of lens wear (F = 119.7, p < 0.001) and was reduced by daily disposable lens wear (F = 7.88, p < 0.001), but did not differ between lenses (F = 0.88, p = 0.45).
Conclusions: Objective measures of tear film indicated a difference between the lenses evaluated for PLNITBUT and tear prism height, but not for wearing time or bulbar conjunctival hyperaemia. Therefore clinical benefits of daily disposable ‘comfort enhancing’ contact lenses can be measured, but challenges
remain in producing contact lenses that do not compromise anterior eye physiology over the whole day.
2010 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalContact Lens and Anterior Eye
Issue number2
Early online date9 Feb 2010
Publication statusPublished - Apr 2010


  • adult
  • conjunctivitis
  • hydrophilic contact lenses
  • disposable equipment
  • dry eye syndromes
  • equipment failure analysis
  • female
  • humans
  • hyperemia
  • male
  • prosthesis design
  • tears
  • treatment outcome


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