TY - JOUR
T1 - On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols
AU - Zhang, Zheng
AU - Santangelo, Diana L.
AU - ten Brink, Gert
AU - Kooi, Bart J.
AU - Moulijn, Jacob A.
AU - Melián-Cabrera, Ignacio
PY - 2014/9/15
Y1 - 2014/9/15
N2 - The effect of the mild detemplation method, based on Fenton chemistry (with and without previous solvent extraction), and calcination was evaluated by the drug uptake capacity of SBA-15 materials. A number of characterization techniques were applied for evaluation and comparison of the materials properties such as TGA, CNH, N2 physisorption and 29Si NMR. The mild Fenton detemplation method rendered a nearly pristine SBA-15 without structural shrinkage, low residual template, improved surface area, pore volume and silanol concentration. The drug (ibuprofen) adsorption experiments were carried out by solution immersion in powdery form. The mild detemplated samples experienced an enhanced uptake that could be explained by the enhanced density of silanols (mmol/g), originated from the absence of calcination in the Fenton approaches.
AB - The effect of the mild detemplation method, based on Fenton chemistry (with and without previous solvent extraction), and calcination was evaluated by the drug uptake capacity of SBA-15 materials. A number of characterization techniques were applied for evaluation and comparison of the materials properties such as TGA, CNH, N2 physisorption and 29Si NMR. The mild Fenton detemplation method rendered a nearly pristine SBA-15 without structural shrinkage, low residual template, improved surface area, pore volume and silanol concentration. The drug (ibuprofen) adsorption experiments were carried out by solution immersion in powdery form. The mild detemplated samples experienced an enhanced uptake that could be explained by the enhanced density of silanols (mmol/g), originated from the absence of calcination in the Fenton approaches.
KW - adsorption capacity
KW - drug delivery systems
KW - ibuprofen
KW - mild detemplation
KW - SBA-15
KW - structured mesoporous materials
UR - http://www.scopus.com/inward/record.url?scp=84903154239&partnerID=8YFLogxK
U2 - 10.1016/j.matlet.2014.05.173
DO - 10.1016/j.matlet.2014.05.173
M3 - Article
AN - SCOPUS:84903154239
SN - 0167-577X
VL - 131
SP - 186
EP - 189
JO - Materials Letters
JF - Materials Letters
ER -