On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols

Zheng Zhang, Diana L. Santangelo, Gert ten Brink, Bart J. Kooi, Jacob A. Moulijn, Ignacio Melián-Cabrera*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The effect of the mild detemplation method, based on Fenton chemistry (with and without previous solvent extraction), and calcination was evaluated by the drug uptake capacity of SBA-15 materials. A number of characterization techniques were applied for evaluation and comparison of the materials properties such as TGA, CNH, N2 physisorption and 29Si NMR. The mild Fenton detemplation method rendered a nearly pristine SBA-15 without structural shrinkage, low residual template, improved surface area, pore volume and silanol concentration. The drug (ibuprofen) adsorption experiments were carried out by solution immersion in powdery form. The mild detemplated samples experienced an enhanced uptake that could be explained by the enhanced density of silanols (mmol/g), originated from the absence of calcination in the Fenton approaches.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalMaterials Letters
Volume131
Early online date1 Jun 2014
DOIs
Publication statusPublished - 15 Sep 2014

Fingerprint

Calcination
roasting
drugs
Adsorption
solvent extraction
Physisorption
adsorption
Ibuprofen
Solvent extraction
shrinkage
Pharmaceutical Preparations
submerging
Materials properties
templates
Nuclear magnetic resonance
chemistry
porosity
nuclear magnetic resonance
evaluation
Experiments

Keywords

  • adsorption capacity
  • drug delivery systems
  • ibuprofen
  • mild detemplation
  • SBA-15
  • structured mesoporous materials

Cite this

Zhang, Z., Santangelo, D. L., ten Brink, G., Kooi, B. J., Moulijn, J. A., & Melián-Cabrera, I. (2014). On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols. Materials Letters, 131, 186-189. https://doi.org/10.1016/j.matlet.2014.05.173
Zhang, Zheng ; Santangelo, Diana L. ; ten Brink, Gert ; Kooi, Bart J. ; Moulijn, Jacob A. ; Melián-Cabrera, Ignacio. / On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols. In: Materials Letters. 2014 ; Vol. 131. pp. 186-189.
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Zhang, Z, Santangelo, DL, ten Brink, G, Kooi, BJ, Moulijn, JA & Melián-Cabrera, I 2014, 'On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols', Materials Letters, vol. 131, pp. 186-189. https://doi.org/10.1016/j.matlet.2014.05.173

On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols. / Zhang, Zheng; Santangelo, Diana L.; ten Brink, Gert; Kooi, Bart J.; Moulijn, Jacob A.; Melián-Cabrera, Ignacio.

In: Materials Letters, Vol. 131, 15.09.2014, p. 186-189.

Research output: Contribution to journalArticle

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Zhang Z, Santangelo DL, ten Brink G, Kooi BJ, Moulijn JA, Melián-Cabrera I. On the drug adsorption capacity of SBA-15 obtained from various detemplation protocols. Materials Letters. 2014 Sep 15;131:186-189. https://doi.org/10.1016/j.matlet.2014.05.173