Optical fine-needle aspiration biopsy in a rat model

Viktor Dremin*, Elena Potapova, Evgeny Zherebtsov, Igor Kozlov, Evgeniya Seryogina, Ksenia Kandurova, Alexander Alekseyev, Gennadii Piavchenko, Sergey Kuznetsov, Andrian Mamoshin, Andrey Dunaev

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Fine needle aspiration biopsy technique and following histological examination show its effectiveness and safety but its performing takes several time. However, the problem of real-time analysis of pathological changes in tissues remains relevant. We demonstrate optical fine-needle biopsy method, combining a fine needle (17.5G) and a fiber-optic probe (1 mm diameter) for minimally invasive interrogation of tissue in vivo. During rat tumor experiment, we collected spectrally-resolved diffuse reflectance and fluorescence. Quantified differences between tumor and normal tissues were demonstrated and approved with morphological analysis. The proposed methodology seems promising for developing new diagnostic criteria for clinical practice.

Original languageEnglish
Article number108770K
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publication statusPublished - 1 Mar 2019
EventDynamics and Fluctuations in Biomedical Photonics XVI 2019 - San Francisco, United States
Duration: 2 Feb 20193 Feb 2019

Bibliographical note

Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.


  • diffuse reectance spectroscopy
  • fine-needle aspiration biopsy
  • minimally invasive surgery
  • optical biopsy
  • tumor
  • uorescence spectroscopy


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