Optical fine-needle aspiration biopsy in a rat model

Viktor Dremin; Elena Potapova; Evgeny Zherebtsov; Igor Kozlov; Evgeniya Seryogina; Ksenia Kandurova; Alexander Alekseyev; Gennadii Piavchenko; Sergey Kuznetsov; Andrian Mamoshin; Andrey Dunaev

doi:10.1117/12.2509255

Optical fine-needle aspiration biopsy in a rat model

Viktor Dremin^*, Elena Potapova, Evgeny Zherebtsov, Igor Kozlov, Evgeniya Seryogina, Ksenia Kandurova, Alexander Alekseyev, Gennadii Piavchenko, Sergey Kuznetsov, Andrian Mamoshin, Andrey Dunaev

^*Corresponding author for this work

Aston Institute of Photonic Technologies (AiPT)

Research output: Contribution to journal › Conference article › peer-review

Abstract

Fine needle aspiration biopsy technique and following histological examination show its effectiveness and safety but its performing takes several time. However, the problem of real-time analysis of pathological changes in tissues remains relevant. We demonstrate optical fine-needle biopsy method, combining a fine needle (17.5G) and a fiber-optic probe (1 mm diameter) for minimally invasive interrogation of tissue in vivo. During rat tumor experiment, we collected spectrally-resolved diffuse reflectance and fluorescence. Quantified differences between tumor and normal tissues were demonstrated and approved with morphological analysis. The proposed methodology seems promising for developing new diagnostic criteria for clinical practice.

Original language	English
Article number	108770K
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10877
DOIs	https://doi.org/10.1117/12.2509255
Publication status	Published - 1 Mar 2019
Event	Dynamics and Fluctuations in Biomedical Photonics XVI 2019 - San Francisco, United States Duration: 2 Feb 2019 → 3 Feb 2019

Bibliographical note

Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

diffuse reectance spectroscopy
fine-needle aspiration biopsy
minimally invasive surgery
optical biopsy
tumor
uorescence spectroscopy

Access to Document

10.1117/12.2509255

Optical fine-needle aspiration biopsy in a rat model
Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Final published version, 2.66 MB

Cite this

@article{9e57878367da4b909425dbabc6bf96c5,

title = "Optical fine-needle aspiration biopsy in a rat model",

abstract = "Fine needle aspiration biopsy technique and following histological examination show its effectiveness and safety but its performing takes several time. However, the problem of real-time analysis of pathological changes in tissues remains relevant. We demonstrate optical fine-needle biopsy method, combining a fine needle (17.5G) and a fiber-optic probe (1 mm diameter) for minimally invasive interrogation of tissue in vivo. During rat tumor experiment, we collected spectrally-resolved diffuse reflectance and fluorescence. Quantified differences between tumor and normal tissues were demonstrated and approved with morphological analysis. The proposed methodology seems promising for developing new diagnostic criteria for clinical practice.",

keywords = "diffuse reectance spectroscopy, fine-needle aspiration biopsy, minimally invasive surgery, optical biopsy, tumor, uorescence spectroscopy",

author = "Viktor Dremin and Elena Potapova and Evgeny Zherebtsov and Igor Kozlov and Evgeniya Seryogina and Ksenia Kandurova and Alexander Alekseyev and Gennadii Piavchenko and Sergey Kuznetsov and Andrian Mamoshin and Andrey Dunaev",

note = "Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. ; Dynamics and Fluctuations in Biomedical Photonics XVI 2019 ; Conference date: 02-02-2019 Through 03-02-2019",

year = "2019",

month = mar,

day = "1",

doi = "10.1117/12.2509255",

language = "English",

volume = "10877",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

issn = "1605-7422",

publisher = "SPIE",

}

TY - JOUR

T1 - Optical fine-needle aspiration biopsy in a rat model

AU - Dremin, Viktor

AU - Potapova, Elena

AU - Zherebtsov, Evgeny

AU - Kozlov, Igor

AU - Seryogina, Evgeniya

AU - Kandurova, Ksenia

AU - Alekseyev, Alexander

AU - Piavchenko, Gennadii

AU - Kuznetsov, Sergey

AU - Mamoshin, Andrian

AU - Dunaev, Andrey

N1 - Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Fine needle aspiration biopsy technique and following histological examination show its effectiveness and safety but its performing takes several time. However, the problem of real-time analysis of pathological changes in tissues remains relevant. We demonstrate optical fine-needle biopsy method, combining a fine needle (17.5G) and a fiber-optic probe (1 mm diameter) for minimally invasive interrogation of tissue in vivo. During rat tumor experiment, we collected spectrally-resolved diffuse reflectance and fluorescence. Quantified differences between tumor and normal tissues were demonstrated and approved with morphological analysis. The proposed methodology seems promising for developing new diagnostic criteria for clinical practice.

AB - Fine needle aspiration biopsy technique and following histological examination show its effectiveness and safety but its performing takes several time. However, the problem of real-time analysis of pathological changes in tissues remains relevant. We demonstrate optical fine-needle biopsy method, combining a fine needle (17.5G) and a fiber-optic probe (1 mm diameter) for minimally invasive interrogation of tissue in vivo. During rat tumor experiment, we collected spectrally-resolved diffuse reflectance and fluorescence. Quantified differences between tumor and normal tissues were demonstrated and approved with morphological analysis. The proposed methodology seems promising for developing new diagnostic criteria for clinical practice.

KW - diffuse reectance spectroscopy

KW - fine-needle aspiration biopsy

KW - minimally invasive surgery

KW - optical biopsy

KW - tumor

KW - uorescence spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85066798167&partnerID=8YFLogxK

UR - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10877/2509255/Optical-fine-needle-aspiration-biopsy-in-a-rat-model/10.1117/12.2509255.full

U2 - 10.1117/12.2509255

DO - 10.1117/12.2509255

M3 - Conference article

AN - SCOPUS:85066798167

SN - 1605-7422

VL - 10877

JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

M1 - 108770K

T2 - Dynamics and Fluctuations in Biomedical Photonics XVI 2019

Y2 - 2 February 2019 through 3 February 2019

ER -

Optical fine-needle aspiration biopsy in a rat model

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this