Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 208-212 |
| Number of pages | 5 |
| Journal | Synthesis |
| Volume | 2004 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2004 |
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Keywords
- ionic liquids
- N-alkylation
- phthalimide
- heterocycle
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Organic reactions in ionic liquids: N-alkylation of phthalimide and several nitrogen heterocycles. / Le, Zhang-Gao; Chen, Zhen-Chu; Hu, Yi; Zheng, Qinguo.
In: Synthesis, Vol. 2004, No. 2, 02.2004, p. 208-212.Research output: Contribution to journal › Article
TY - JOUR
T1 - Organic reactions in ionic liquids: N-alkylation of phthalimide and several nitrogen heterocycles
AU - Le, Zhang-Gao
AU - Chen, Zhen-Chu
AU - Hu, Yi
AU - Zheng, Qinguo
PY - 2004/2
Y1 - 2004/2
N2 - N-Alkylation of heterocyclic compounds bearing an acidic hydrogen atom attached to nitrogen with alkyl halides is accomplished in ionic liquids ([bmim]BF4 = 1-butyl-3-methylimidazolium tetrafluoroborate, [bmim]PF6 = 1-butyl-3-methylimida-zolium hexafluorophosphate, [buPy]BF4 = butylpyridinium tetrafluoroborate) in the presence of potassium hydroxide as a base. In this manner, phthalimide, indole, benzimidazole, succinimide can be successfully alkylated. The procedure is convenient, efficient, and generally affords the N-alkylated product exclusively.
AB - N-Alkylation of heterocyclic compounds bearing an acidic hydrogen atom attached to nitrogen with alkyl halides is accomplished in ionic liquids ([bmim]BF4 = 1-butyl-3-methylimidazolium tetrafluoroborate, [bmim]PF6 = 1-butyl-3-methylimida-zolium hexafluorophosphate, [buPy]BF4 = butylpyridinium tetrafluoroborate) in the presence of potassium hydroxide as a base. In this manner, phthalimide, indole, benzimidazole, succinimide can be successfully alkylated. The procedure is convenient, efficient, and generally affords the N-alkylated product exclusively.
KW - ionic liquids
KW - N-alkylation
KW - phthalimide
KW - heterocycle
UR - https://www.thieme-connect.de/ejournals/abstract/synthesis/doi/10.1055/s-2003-44383
U2 - 10.1055/s-2003-44383
DO - 10.1055/s-2003-44383
M3 - Article
VL - 2004
SP - 208
EP - 212
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 2
ER -