Pediatric Autoimmune Epileptic Encephalopathies

Sukhvir Wright*, Angela Vincent

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Pediatric autoimmune epileptic encephalopathies are predominantly characterized by the presence of autoantibodies to the surface of neuronal proteins, for example, N-methyl-d-aspartate (NMDA) receptor antibodies, but also include diseases with non-cell surface antibodies (eg, anti-Hu, glutamic-acid decarboxylase antibodies). In some cases with distinct clinical and para-clinical features, an autoimmune epileptic encephalopathy can be diagnosed without the presence of an antibody and will also respond favorably to immunotherapy. In this review, we summarize the common presentations of pediatric autoimmune epileptic encephalopathies, treatments, and outcomes, and report recent findings in the field of epilepsy, encephalopathy, and the immune system.

Original languageEnglish
Pages (from-to)418-428
Number of pages11
JournalJournal of Child Neurology
Volume32
Issue number4
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • autoantibodies
  • autoimmune epilepsy
  • encephalopathy
  • NMDA receptor antibody encephalitis
  • voltage-gated potassium channel complex

Fingerprint Dive into the research topics of 'Pediatric Autoimmune Epileptic Encephalopathies'. Together they form a unique fingerprint.

  • Cite this