The dimethyl-xanthine derivative pentoxifylline (PTX) increases blood flow through capillaries. In elderly humans the drug leads to improvement in a number of imapired neuropsychological parameters. We now report that oral administration to 29-month female mice (C57, black and tan) over six days induced four different patterns of behavioural reponse: (1) consistent improvement in grooming behaviour throughout the six day trial; (2) significant improvement in light/dark zone curiosity and curiosity towards a strange object on day three, which declined but remained significantly above pre-treatment levels at day 6; (3) an improvement in general activity which only becomes detectable on day six; (4) a significant improvement in rod-walking, rearing an shuttle-box crosses on day three which returned to pre-treatment levels by day 6. Age-related deficits in general activity, grooming and curiosity were completely eliminated by the drug - the mean group performance levels attained those seen in 9-12 month individuals of this strain.
|Publication status||Unpublished - 1987|
|Event||Fifth Meeting of the Brain Research Association - Edinburgh (UK)|
Duration: 29 Mar 1987 → 1 Apr 1987
|Conference||Fifth Meeting of the Brain Research Association|
|Period||29/03/87 → 1/04/87|
Bibliographical noteAbstract appearing in Abstracts of the fifth meeting of the Brain Research Association. Edinburgh, Scotland, U.K., March 29-April 1, 1987. Neuroscience Letters, 29 (Suppl. 1), p.150.
- dimethyl-xanthine derivative pentoxifylline
- blood flow
- imapired neuropsychological parameters