Abstract
Class II Major Histocompatibility Complex (MHC) molecules have an open-ended binding groove which can accommodate peptides of varying lengths. Several studies have demonstrated that peptide flanking residues (PFRs) which lie outside the core binding groove can influence peptide binding and T cell recognition. By using data from the AntiJen database we were able to characterise systematically the influence of PFRs on peptide affinity for MHC class II molecules.
Original language | English |
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Article number | 6 |
Number of pages | 7 |
Journal | Immunome Research |
Volume | 4 |
Issue number | 6 |
DOIs | |
Publication status | Published - 26 Nov 2008 |
Bibliographical note
© 2008 O'Brien et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.