Class II Major Histocompatibility Complex (MHC) molecules have an open-ended binding groove which can accommodate peptides of varying lengths. Several studies have demonstrated that peptide flanking residues (PFRs) which lie outside the core binding groove can influence peptide binding and T cell recognition. By using data from the AntiJen database we were able to characterise systematically the influence of PFRs on peptide affinity for MHC class II molecules.
|Number of pages||7|
|Publication status||Published - 26 Nov 2008|
Bibliographical note© 2008 O'Brien et al; licensee BioMed Central Ltd.
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