Preformulation studies on grewia gum as a formulation excipient

Elijah I. Nep, Barbara R. Conway

Research output: Contribution to journalArticle

Abstract

Grewia gum is a naturally occurring polysaccharide which has potential as a pharmaceutical excipient. Differential scanning calorimetry and Fourier transform infrared (FT-IR) spectroscopy techniques were used to examine the thermal and molecular behaviours, respectively, of mixtures of grewia gum with cimetidine, ibuprofen or standard excipients, to assess potential interactions. No disappearance or broadening of the melting endotherm was seen with cimetidine or ibuprofen. Similarly, there was no interaction between grewia gum and the standard excipients tested. The results obtained using thermal analyses were supported by FT-IR analysis of the material mixtures. Grewia gum is an inert natural polymer which can be used alone or in combination with other excipients in the formulation of pharmaceutical dosage forms.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalJournal of Thermal Analysis and Calorimetry
Volume108
Issue number1
Early online date17 Jul 2011
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Excipients
Drug products
Natural polymers
formulations
Ibuprofen
polysaccharides
Cimetidine
Polysaccharides
Fourier transform infrared spectroscopy
Differential scanning calorimetry
Fourier transforms
Melting
heat measurement
infrared spectroscopy
melting
interactions
Infrared radiation
dosage
scanning
Dosage Forms

Keywords

  • cimetidine
  • DSC
  • excipients
  • FT-IR
  • grewia gum
  • ibuprofen

Cite this

Nep, Elijah I. ; Conway, Barbara R. / Preformulation studies on grewia gum as a formulation excipient. In: Journal of Thermal Analysis and Calorimetry. 2012 ; Vol. 108, No. 1. pp. 197-205.
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Preformulation studies on grewia gum as a formulation excipient. / Nep, Elijah I.; Conway, Barbara R.

In: Journal of Thermal Analysis and Calorimetry, Vol. 108, No. 1, 04.2012, p. 197-205.

Research output: Contribution to journalArticle

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