Real-time label-free biosensing with integrated planar waveguide ring resonators

Hans Sohlström*, Kristinn B. Gylfason, Daniel Hill

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

We review the use of planar integrated optical waveguide ring resonators for label free bio-sensing and present recent results from two European biosensor collaborations: SABIO and InTopSens. Planar waveguide ring resonators are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the optical chip and integration with microfluidics. From the SABIO project we report refractive index measurement and label-free biosensing in an 8-channel slotwaveguide ring resonator sensor array, within a compact cartridge with integrated microfluidics. The sensors show a volume sensing detection limit of 5 × 10-6 RIU and a surface sensing detection limit of 0.9 pg/mm2. From the InTopSens project we report early results on silicon-on-insulator racetrack resonators.

Original languageEnglish
Article number77190B
JournalProceedings of SPIE - International Society for Optical Engineering
Volume7719
DOIs
Publication statusPublished - 17 May 2010
EventSilicon Photonics and Photonic Integrated Circuits II - Brussels, Belgium
Duration: 12 Apr 201016 Apr 2010

Fingerprint

Biosensing
Planar Waveguides
Ring Resonator
Planar waveguides
Sensor Array
Labels
Resonators
Microfluidics
Sensor arrays
Chip
resonators
waveguides
Real-time
Detection Limit
rings
chips
Sensing
sensors
Silicon-on-insulator
Biosensor

Bibliographical note

Copyright 2010 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

  • biosensing
  • lab-on-chip
  • label-free
  • light-coupling
  • microfluidics
  • packaging
  • ring resonators
  • slot waveguide

Cite this

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abstract = "We review the use of planar integrated optical waveguide ring resonators for label free bio-sensing and present recent results from two European biosensor collaborations: SABIO and InTopSens. Planar waveguide ring resonators are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the optical chip and integration with microfluidics. From the SABIO project we report refractive index measurement and label-free biosensing in an 8-channel slotwaveguide ring resonator sensor array, within a compact cartridge with integrated microfluidics. The sensors show a volume sensing detection limit of 5 × 10-6 RIU and a surface sensing detection limit of 0.9 pg/mm2. From the InTopSens project we report early results on silicon-on-insulator racetrack resonators.",
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Real-time label-free biosensing with integrated planar waveguide ring resonators. / Sohlström, Hans; Gylfason, Kristinn B.; Hill, Daniel.

In: Proceedings of SPIE - International Society for Optical Engineering, Vol. 7719, 77190B, 17.05.2010.

Research output: Contribution to journalConference article

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AU - Gylfason, Kristinn B.

AU - Hill, Daniel

N1 - Copyright 2010 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

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