Real-time label-free biosensing with integrated planar waveguide ring resonators

Hans Sohlström*, Kristinn B. Gylfason, Daniel Hill

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

We review the use of planar integrated optical waveguide ring resonators for label free bio-sensing and present recent results from two European biosensor collaborations: SABIO and InTopSens. Planar waveguide ring resonators are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the optical chip and integration with microfluidics. From the SABIO project we report refractive index measurement and label-free biosensing in an 8-channel slotwaveguide ring resonator sensor array, within a compact cartridge with integrated microfluidics. The sensors show a volume sensing detection limit of 5 × 10-6 RIU and a surface sensing detection limit of 0.9 pg/mm2. From the InTopSens project we report early results on silicon-on-insulator racetrack resonators.

Original languageEnglish
Article number77190B
JournalProceedings of SPIE - International Society for Optical Engineering
Volume7719
DOIs
Publication statusPublished - 17 May 2010
EventSilicon Photonics and Photonic Integrated Circuits II - Brussels, Belgium
Duration: 12 Apr 201016 Apr 2010

Bibliographical note

Copyright 2010 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

  • biosensing
  • lab-on-chip
  • label-free
  • light-coupling
  • microfluidics
  • packaging
  • ring resonators
  • slot waveguide

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