Recent patents and trends in orally disintegrating tablets

Farhan A AlHusban, Amr M El-Shaer, Rhys J Jones, Afzal R Mohammed

Research output: Contribution to journalArticle

Abstract

Orally disintegrating tablets (ODTs) offer many advantages over the conventional oral dosage forms in terms of convenience and ease of use. Over the last decade, substantial advances in the formulation of ODTs have been achieved in academia and industry that resulted in the emerging of a large number of patents. The aim of this review is to summarise the most recent patents in ODT formulations and highlight their motivations, inventive steps and significances in the development of ODT formulations. Five major techniques have been applied in manufacturing of ODTs, namely conventional tablet press, moulding, freeze drying, tablet loading and pulverization, with majority of the patents dedicated to the use of conventional tablet pressing. The patents have addressed various issues concerning the manufacturing of robust and practical ODT formulations by disclosing new manufacturing techniques, advantageous materials, and innovative formulation steps. However, future developments are required to reduce the cost and widening the application of the new manufacturing techniques, while simplifying and shortening the formulation steps will be crucial in the well established ones.
LanguageEnglish
Pages178-197
Number of pages20
JournalRecent patents on drug delivery and formulation
Volume4
Issue number3
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Patents
Tablets
Molding
Drying
Freeze Drying
Dosage Forms
Costs
Industry
Costs and Cost Analysis

Keywords

  • pharmaceutical chemistry
  • drug design
  • drug industry
  • humans
  • patents as topic
  • pharmaceutical preparations
  • tablets
  • pharmaceutical technology

Cite this

AlHusban, Farhan A ; El-Shaer, Amr M ; Jones, Rhys J ; Mohammed, Afzal R. / Recent patents and trends in orally disintegrating tablets. In: Recent patents on drug delivery and formulation. 2010 ; Vol. 4, No. 3. pp. 178-197.
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Recent patents and trends in orally disintegrating tablets. / AlHusban, Farhan A; El-Shaer, Amr M; Jones, Rhys J; Mohammed, Afzal R.

In: Recent patents on drug delivery and formulation, Vol. 4, No. 3, 11.2010, p. 178-197.

Research output: Contribution to journalArticle

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