Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels

Robert H. Morris, Martin Bencsik, Nikolaus Nestle, Petrik Galvosas, David Fairhurst, Anil Vangala, Yvonne Perrie, Glen McHale

Research output: Contribution to journalArticle

Abstract

MRI of fluids containing lipid coated microbubbles has been shown to be an effective toot for measuring the local fluid pressure. However, the intrinsically buoyant nature of these microbubbles precludes lengthy measurements due to their vertical migration under gravity and pressure-induced coalescence. A novel preparation is presented which is shown to minimize both these effects for at least 25 min. By using a 2% polysaccharide gel base with a small concentration of glycerol and 1,2-distearoyl-sn-glycero-3-phosphocholine coated gas microbubbles, MR measurements are made for pressures between 0.95 and 1.44 bar. The signal drifts due to migration and amalgamation are shown to be minimized for such an experiment whilst yielding very high NMR sensitivities up to 38% signal change per bar.
Original languageEnglish
Pages (from-to)159-167
Number of pages9
JournalJournal of Magnetic Resonance
Volume193
Issue number2
DOIs
Publication statusPublished - Aug 2008

Keywords

  • gas filled lipid coated microbubbles
  • pressure
  • polysaccharide
  • MRI
  • diffusion
  • viscosity
  • contrast agent

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