Sampling volume assessment for wearable multimodal optical diagnostic device

Elena Zharkikh; Viktor V. Dremin; Andrey Dunaev

doi:10.1002/JBIO.202300139

Sampling volume assessment for wearable multimodal optical diagnostic device

Elena Zharkikh, Viktor V. Dremin, Andrey Dunaev

Aston Institute of Photonic Technologies (AiPT)

Research output: Contribution to journal › Article › peer-review

Abstract

The process and results of numerical Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS) channels of a wearable diagnostic multimodal device are described in this paper. To achieve the goal, a multilayer skin model with different parameters of blood and melanin content and different distances between sources and radiation receivers was designed. The changes in the sampling (diagnostic) volume depending on the anatomical features of the biological tissues, as well as on the technical parameters of the device were shown. Depending on the scattering media optical properties and the source-detector configuration of the device, the diagnostic volume can range from 2 to 7 mm ³. The obtained results allow the formation of specialized medical and technical requirements for wearable multimodal devices implementing LDF and FS channels.

Original language	English
Article number	e202300139
Number of pages	11
Journal	Journal of Biophotonics
Volume	16
Issue number	9
Early online date	16 Jun 2023
DOIs	https://doi.org/10.1002/JBIO.202300139
Publication status	Published - Sept 2023

Bibliographical note

Funding Information:
This work was supported by the Russian Science Foundation under Project No. 23‐25‐00522.

Publisher Copyright:
This is the peer reviewed version of the following article: V. Zharkikh, E., V. Dremin, V., V. Dunaev, A., J. Biophotonics 2023, 16(9), e202300139, which has been published in final form at https://doi.org/10.1002/jbio.202300139. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited

Keywords

Monte Carlo simulations
fluorescence spectroscopy
laser doppler flowmetry
optical noninvasive diagnostics
optical properties
wearable device

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10.1002/JBIO.202300139

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title = "Sampling volume assessment for wearable multimodal optical diagnostic device",

abstract = "The process and results of numerical Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS) channels of a wearable diagnostic multimodal device are described in this paper. To achieve the goal, a multilayer skin model with different parameters of blood and melanin content and different distances between sources and radiation receivers was designed. The changes in the sampling (diagnostic) volume depending on the anatomical features of the biological tissues, as well as on the technical parameters of the device were shown. Depending on the scattering media optical properties and the source-detector configuration of the device, the diagnostic volume can range from 2 to 7 mm 3. The obtained results allow the formation of specialized medical and technical requirements for wearable multimodal devices implementing LDF and FS channels.",

keywords = "Monte Carlo simulations, fluorescence spectroscopy, laser doppler flowmetry, optical noninvasive diagnostics, optical properties, wearable device",

author = "Elena Zharkikh and Dremin, {Viktor V.} and Andrey Dunaev",

note = "Funding Information: This work was supported by the Russian Science Foundation under Project No. 23‐25‐00522. Publisher Copyright: This is the peer reviewed version of the following article: V. Zharkikh, E., V. Dremin, V., V. Dunaev, A., J. Biophotonics 2023, 16(9), e202300139, which has been published in final form at https://doi.org/10.1002/jbio.202300139. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley{\textquoteright}s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited",

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AU - Dremin, Viktor V.

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N1 - Funding Information: This work was supported by the Russian Science Foundation under Project No. 23‐25‐00522. Publisher Copyright: This is the peer reviewed version of the following article: V. Zharkikh, E., V. Dremin, V., V. Dunaev, A., J. Biophotonics 2023, 16(9), e202300139, which has been published in final form at https://doi.org/10.1002/jbio.202300139. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited

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N2 - The process and results of numerical Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS) channels of a wearable diagnostic multimodal device are described in this paper. To achieve the goal, a multilayer skin model with different parameters of blood and melanin content and different distances between sources and radiation receivers was designed. The changes in the sampling (diagnostic) volume depending on the anatomical features of the biological tissues, as well as on the technical parameters of the device were shown. Depending on the scattering media optical properties and the source-detector configuration of the device, the diagnostic volume can range from 2 to 7 mm 3. The obtained results allow the formation of specialized medical and technical requirements for wearable multimodal devices implementing LDF and FS channels.

AB - The process and results of numerical Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS) channels of a wearable diagnostic multimodal device are described in this paper. To achieve the goal, a multilayer skin model with different parameters of blood and melanin content and different distances between sources and radiation receivers was designed. The changes in the sampling (diagnostic) volume depending on the anatomical features of the biological tissues, as well as on the technical parameters of the device were shown. Depending on the scattering media optical properties and the source-detector configuration of the device, the diagnostic volume can range from 2 to 7 mm 3. The obtained results allow the formation of specialized medical and technical requirements for wearable multimodal devices implementing LDF and FS channels.

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Sampling volume assessment for wearable multimodal optical diagnostic device

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Keywords

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