Soft hydrogels from nanotubes of poly(ethylene oxide)−tetraphenylalanine conjugates prepared by click chemistry

N. Tzokova, C.M. Fernyhough, Paul D. Topham, N. Sandon, S.P. Armes, A.J. Ryan, D.J. Adams, M.F. Butler

Research output: Contribution to journalArticle

Abstract

A new poly(ethylene oxide)-tetraphenylalanine polymer-peptide conjugate has been prepared via a “click” reaction between an alkyne-modified peptide and an azide-terminated PEO oligomer. Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer-peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel ß-sheets and p-p-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL-1. Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer-peptide conjugate concentration, as expected.
LanguageEnglish
Pages2479-2485
Number of pages7
JournalLangmuir
Volume25
Issue number4
DOIs
Publication statusPublished - 22 Jan 2009

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Hydrogels
ethylene oxide
Polyethylene oxides
Nanotubes
Peptides
peptides
nanotubes
chemistry
Polymers
dialysis
high polymers
Alkynes
Dialysis
Azides
polymers
Dichroism
alkynes
oligomers
Oligomers
Self assembly

Keywords

  • chemistry
  • click chemistry
  • nanotubes

Cite this

Tzokova, N., Fernyhough, C. M., Topham, P. D., Sandon, N., Armes, S. P., Ryan, A. J., ... Butler, M. F. (2009). Soft hydrogels from nanotubes of poly(ethylene oxide)−tetraphenylalanine conjugates prepared by click chemistry. Langmuir, 25(4), 2479-2485. https://doi.org/10.1021/la8035659
Tzokova, N. ; Fernyhough, C.M. ; Topham, Paul D. ; Sandon, N. ; Armes, S.P. ; Ryan, A.J. ; Adams, D.J. ; Butler, M.F. / Soft hydrogels from nanotubes of poly(ethylene oxide)−tetraphenylalanine conjugates prepared by click chemistry. In: Langmuir. 2009 ; Vol. 25, No. 4. pp. 2479-2485.
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Tzokova, N, Fernyhough, CM, Topham, PD, Sandon, N, Armes, SP, Ryan, AJ, Adams, DJ & Butler, MF 2009, 'Soft hydrogels from nanotubes of poly(ethylene oxide)−tetraphenylalanine conjugates prepared by click chemistry' Langmuir, vol. 25, no. 4, pp. 2479-2485. https://doi.org/10.1021/la8035659

Soft hydrogels from nanotubes of poly(ethylene oxide)−tetraphenylalanine conjugates prepared by click chemistry. / Tzokova, N.; Fernyhough, C.M.; Topham, Paul D.; Sandon, N.; Armes, S.P.; Ryan, A.J.; Adams, D.J.; Butler, M.F.

In: Langmuir, Vol. 25, No. 4, 22.01.2009, p. 2479-2485.

Research output: Contribution to journalArticle

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