Solid bridge formation between spray-dried sodium carbonate particles

Mark Leaper; D.C. Prime; P.M. Taylor; V. Leach

doi:10.1080/07373937.2012.682287

Solid bridge formation between spray-dried sodium carbonate particles

Mark Leaper, D.C. Prime, P.M. Taylor, V. Leach

Chemical Engineering & Applied Chemistry

Research output: Contribution to journal › Special issue › peer-review

Abstract

Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.

Original language	English
Pages (from-to)	1008-1013
Number of pages	6
Journal	Drying Technology
Volume	30
Issue number	9
DOIs	https://doi.org/10.1080/07373937.2012.682287
Publication status	Published - 29 May 2012

Keywords

Atomic Force Microscopy
caking
sodium carbonate
spray-drying

Access to Document

10.1080/07373937.2012.682287

Cite this

@article{e4acc56cf0fc4758b437b12f18ce8e08,

title = "Solid bridge formation between spray-dried sodium carbonate particles",

abstract = "Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.",

keywords = "Atomic Force Microscopy, caking, sodium carbonate, spray-drying",

author = "Mark Leaper and D.C. Prime and P.M. Taylor and V. Leach",

year = "2012",

month = may,

day = "29",

doi = "10.1080/07373937.2012.682287",

language = "English",

volume = "30",

pages = "1008--1013",

journal = "Drying Technology",

issn = "0737-3937",

publisher = "Taylor & Francis",

number = "9",

}

TY - JOUR

T1 - Solid bridge formation between spray-dried sodium carbonate particles

AU - Leaper, Mark

AU - Prime, D.C.

AU - Taylor, P.M.

AU - Leach, V.

PY - 2012/5/29

Y1 - 2012/5/29

N2 - Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.

AB - Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.

KW - Atomic Force Microscopy

KW - caking

KW - sodium carbonate

KW - spray-drying

UR - http://www.scopus.com/inward/record.url?scp=84861935950&partnerID=8YFLogxK

U2 - 10.1080/07373937.2012.682287

DO - 10.1080/07373937.2012.682287

M3 - Special issue

SN - 0737-3937

VL - 30

SP - 1008

EP - 1013

JO - Drying Technology

JF - Drying Technology

IS - 9

ER -

Solid bridge formation between spray-dried sodium carbonate particles

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this