Solid bridge formation between spray-dried sodium carbonate particles

Mark Leaper, D.C. Prime, P.M. Taylor, V. Leach

Research output: Contribution to journalSpecial issue

Abstract

Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.
Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalDrying Technology
Volume30
Issue number9
DOIs
Publication statusPublished - 29 May 2012

Fingerprint

sodium carbonates
sprayers
Carbonates
Sodium
Crystalline materials
cycles
Excipients
moisture
Drug products
Atomic force microscopy
Moisture
atomic force microscopy
expansion
Pharmaceutical Preparations
sodium carbonate

Keywords

  • Atomic Force Microscopy
  • caking
  • sodium carbonate
  • spray-drying

Cite this

Leaper, Mark ; Prime, D.C. ; Taylor, P.M. ; Leach, V. / Solid bridge formation between spray-dried sodium carbonate particles. In: Drying Technology. 2012 ; Vol. 30, No. 9. pp. 1008-1013.
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Leaper, M, Prime, DC, Taylor, PM & Leach, V 2012, 'Solid bridge formation between spray-dried sodium carbonate particles', Drying Technology, vol. 30, no. 9, pp. 1008-1013. https://doi.org/10.1080/07373937.2012.682287

Solid bridge formation between spray-dried sodium carbonate particles. / Leaper, Mark; Prime, D.C.; Taylor, P.M.; Leach, V.

In: Drying Technology, Vol. 30, No. 9, 29.05.2012, p. 1008-1013.

Research output: Contribution to journalSpecial issue

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AU - Leaper, Mark

AU - Prime, D.C.

AU - Taylor, P.M.

AU - Leach, V.

PY - 2012/5/29

Y1 - 2012/5/29

N2 - Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.

AB - Moisture migration caking of pharmaceutical excipients in the absence of load is a significant quality and stability issue. This study uses Atomic Force Microscopy (AFM) to examine a solid bridge formed between two 20µm spray-dried sodium carbonate particles. The bridge is grown by repeatedly exposing the system to 70% RH and 30% RH cycles at 25?C. A comparison is made with the idealised bridge model developed by Tanaka (1978) which was previously verified using crystalline systems. The resulting system was found to be more complex and grew in two stages. The first stage consisted of linear growth to 5 cycles, followed by a more gradual expansion and the appearance of crystalline structures.

KW - Atomic Force Microscopy

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