Abstract
In sporadic Alzheimer's disease (SAD), the classic ('dense-cored') β-amyloid (Aβ) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic b-amyloid (Aβ deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aβ and with collagen IV to reveal the Aβ deposits and blood vessel profiles. In the FAD cases as a whole, Aβdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aβdeposits and the larger (>10 μm) and smaller diameter (<10 μm) blood vessels in one and three cases respectively. The primitive Aβ deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aβ deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
| Original language | English |
|---|---|
| Pages (from-to) | 241-248 |
| Number of pages | 8 |
| Journal | Folia Neuropathologica |
| Volume | 46 |
| Issue number | 4 |
| Publication status | Published - 1 Jan 2008 |
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Keywords
- Blood vessels
- Clustering
- Diffusion
- Frontal cortex
- Perivascular clearance
- Spatial correlation
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Spatial correlations between β-amyloid (Aβ) deposits and blood vessels in familial Alzheimer's disease. / Armstrong, Richard A.
In: Folia Neuropathologica, Vol. 46, No. 4, 01.01.2008, p. 241-248.Research output: Contribution to journal › Article
TY - JOUR
T1 - Spatial correlations between β-amyloid (Aβ) deposits and blood vessels in familial Alzheimer's disease
AU - Armstrong, Richard A.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - In sporadic Alzheimer's disease (SAD), the classic ('dense-cored') β-amyloid (Aβ) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic b-amyloid (Aβ deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aβ and with collagen IV to reveal the Aβ deposits and blood vessel profiles. In the FAD cases as a whole, Aβdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aβdeposits and the larger (>10 μm) and smaller diameter (<10 μm) blood vessels in one and three cases respectively. The primitive Aβ deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aβ deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
AB - In sporadic Alzheimer's disease (SAD), the classic ('dense-cored') β-amyloid (Aβ) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic b-amyloid (Aβ deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aβ and with collagen IV to reveal the Aβ deposits and blood vessel profiles. In the FAD cases as a whole, Aβdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aβdeposits and the larger (>10 μm) and smaller diameter (<10 μm) blood vessels in one and three cases respectively. The primitive Aβ deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aβ deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
KW - Blood vessels
KW - Clustering
KW - Diffusion
KW - Frontal cortex
KW - Perivascular clearance
KW - Spatial correlation
UR - http://www.scopus.com/inward/record.url?scp=62249133805&partnerID=8YFLogxK
M3 - Article
C2 - 19169965
AN - SCOPUS:62249133805
VL - 46
SP - 241
EP - 248
JO - Folia Neuropathologica
JF - Folia Neuropathologica
SN - 1641-4640
IS - 4
ER -