Spatial patterns of β-amyloid (Aβ) deposits in familial and sporadic Alzheimer's disease

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

The spatial patterns of the diffuse, primitive, and classic β-amyloid (Aβ) deposits were compared in cortical regions in early-onset familial Alzheimer's disease (EO-FAD) linked to mutations of the amyloid precursor protein APP) or presenilin 1 (PSEN1) genes, late-onset familial AD (LO-FAD), and sporadic AD (SAD). The objective was to determine whether genetic factors influenced the spatial patterns of the Aβ deposits. Aβ deposits were distributed either in clusters which were regularly distributed parallel to the pia mater or in larger, non-regularly distributed clusters. There were no significant differences in spatial pattern of the diffuse deposits between patient groups but mean cluster size of the diffuse deposits was larger in FAD compared with SAD. Primitive Aβ deposits were more frequently distributed in regular clusters and less frequently distributed in large clusters in FAD compared with SAD. Classic Aβ deposits were more frequently distributed in regularly spaced clusters and less frequently distributed in large clusters in LO-FAD compared with EO-FAD. There were no significant differences in the spatial patterns or cluster sizes of Aβ deposits in cases classified according to apolipoprotein E (APOE) genotype. These results suggest (1) greater deposition of Aβ in the form of clusters of diffuse deposits in FAD, (2) a greater proportion of diffuse deposits may be converted to primitive deposits in SAD, (3) classic deposits are more widely distributed in EO-FAD, and (4) the presence of APOE allele ε4 has little effect on the spatial patterns of Aβ deposits.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalFolia Neuropathologica
Volume49
Issue number3
Publication statusPublished - 30 Sep 2011

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Amyloid Plaques
Alzheimer Disease
Flavin-Adenine Dinucleotide
Pia Mater
Presenilin-1
Apolipoprotein E4
Amyloid beta-Protein Precursor
Apolipoproteins E
Alleles
Genotype
Mutation
Genes

Bibliographical note

Creative Commons Attribution Non-Commercial Share Alike International 4.0

Keywords

  • alzheimer's disease (AD)
  • amyloid precursor protein (APP)
  • apolipoprotein E (APOE)
  • presenilin 1 (PSEN1)
  • spatial pattern
  • β-amyloid (Aβ) deposits

Cite this

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Spatial patterns of β-amyloid (Aβ) deposits in familial and sporadic Alzheimer's disease. / Armstrong, Richard A.

In: Folia Neuropathologica, Vol. 49, No. 3, 30.09.2011, p. 153-161.

Research output: Contribution to journalArticle

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