Spatial patterns of the tau pathology in progressive supranuclear palsy

Richard A. Armstrong, Nigel J. Cairns

Research output: Contribution to journalArticle

Abstract

Progressive supranuclear palsy (PSP) is characterized neuropathologically by neuronal loss, gliosis, and the presence of tau-immunoreactive neuronal and glial cell inclusions affecting subcortical and some cortical regions. The objectives of this study were to determine (1) the spatial patterns of the tau-immunoreactive pathology, viz., neurofibrillary tangles (NFT), oligodendroglial inclusions (GI), tufted astrocytes (TA), and Alzheimer's disease-type neuritic plaques (NP) in PSP and (2) to investigate the spatial correlations between the histological features. Post-mortem material of cortical and subcortical regions of eight PSP cases was studied. Spatial pattern analysis was applied to the NFT, GI, TA, NP, abnormally enlarged neurons (EN), surviving neurons, and glial cells. NFT, GI, and TA were distributed either at random or in regularly distributed clusters. The EN and NP were mainly randomly distributed. Clustering of NFT and EN was more frequent in the cortex and subcortical regions, respectively. Variations in NFT density were not spatially correlated with the densities of either GI or TA, but were positively correlated with the densities of EN and surviving neurons in some regions. (1) NFT were the most widespread tau-immunoreactive pathology in PSP being distributed randomly in subcortical regions and in regular clusters in cortical regions, (2) GI and TA were more localized and exhibited a regular pattern of clustering in subcortical regions, and (3) neuronal and glial cell pathologies were not spatially correlated. © 2012 Springer-Verlag.

LanguageEnglish
Pages337-344
Number of pages8
JournalNeurological Sciences
Volume34
Issue number3
Early online date13 Mar 2012
DOIs
Publication statusPublished - 2013

Fingerprint

Progressive Supranuclear Palsy
Neurofibrillary Tangles
Astrocytes
Pathology
Neurons
Amyloid Plaques
Neuroglia
Cluster Analysis
Spatial Analysis
Gliosis
Alzheimer Disease

Bibliographical note

The original publication is available at www.springerlink.com

Keywords

  • neurofibrillary tangle (NFT)
  • oligodendroglial inclusion (GI)
  • progressive supranuclear palsy (PSP)
  • spatial pattern
  • tufted astrocyte (TA)

Cite this

Armstrong, Richard A. ; Cairns, Nigel J. / Spatial patterns of the tau pathology in progressive supranuclear palsy. In: Neurological Sciences. 2013 ; Vol. 34, No. 3. pp. 337-344.
@article{940e959d7b97414d88ca3147c7d33bed,
title = "Spatial patterns of the tau pathology in progressive supranuclear palsy",
abstract = "Progressive supranuclear palsy (PSP) is characterized neuropathologically by neuronal loss, gliosis, and the presence of tau-immunoreactive neuronal and glial cell inclusions affecting subcortical and some cortical regions. The objectives of this study were to determine (1) the spatial patterns of the tau-immunoreactive pathology, viz., neurofibrillary tangles (NFT), oligodendroglial inclusions (GI), tufted astrocytes (TA), and Alzheimer's disease-type neuritic plaques (NP) in PSP and (2) to investigate the spatial correlations between the histological features. Post-mortem material of cortical and subcortical regions of eight PSP cases was studied. Spatial pattern analysis was applied to the NFT, GI, TA, NP, abnormally enlarged neurons (EN), surviving neurons, and glial cells. NFT, GI, and TA were distributed either at random or in regularly distributed clusters. The EN and NP were mainly randomly distributed. Clustering of NFT and EN was more frequent in the cortex and subcortical regions, respectively. Variations in NFT density were not spatially correlated with the densities of either GI or TA, but were positively correlated with the densities of EN and surviving neurons in some regions. (1) NFT were the most widespread tau-immunoreactive pathology in PSP being distributed randomly in subcortical regions and in regular clusters in cortical regions, (2) GI and TA were more localized and exhibited a regular pattern of clustering in subcortical regions, and (3) neuronal and glial cell pathologies were not spatially correlated. {\circledC} 2012 Springer-Verlag.",
keywords = "neurofibrillary tangle (NFT), oligodendroglial inclusion (GI), progressive supranuclear palsy (PSP), spatial pattern, tufted astrocyte (TA)",
author = "Armstrong, {Richard A.} and Cairns, {Nigel J.}",
note = "The original publication is available at www.springerlink.com",
year = "2013",
doi = "10.1007/s10072-012-1006-0",
language = "English",
volume = "34",
pages = "337--344",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer",
number = "3",

}

Spatial patterns of the tau pathology in progressive supranuclear palsy. / Armstrong, Richard A.; Cairns, Nigel J.

In: Neurological Sciences, Vol. 34, No. 3, 2013, p. 337-344.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Spatial patterns of the tau pathology in progressive supranuclear palsy

AU - Armstrong, Richard A.

AU - Cairns, Nigel J.

N1 - The original publication is available at www.springerlink.com

PY - 2013

Y1 - 2013

N2 - Progressive supranuclear palsy (PSP) is characterized neuropathologically by neuronal loss, gliosis, and the presence of tau-immunoreactive neuronal and glial cell inclusions affecting subcortical and some cortical regions. The objectives of this study were to determine (1) the spatial patterns of the tau-immunoreactive pathology, viz., neurofibrillary tangles (NFT), oligodendroglial inclusions (GI), tufted astrocytes (TA), and Alzheimer's disease-type neuritic plaques (NP) in PSP and (2) to investigate the spatial correlations between the histological features. Post-mortem material of cortical and subcortical regions of eight PSP cases was studied. Spatial pattern analysis was applied to the NFT, GI, TA, NP, abnormally enlarged neurons (EN), surviving neurons, and glial cells. NFT, GI, and TA were distributed either at random or in regularly distributed clusters. The EN and NP were mainly randomly distributed. Clustering of NFT and EN was more frequent in the cortex and subcortical regions, respectively. Variations in NFT density were not spatially correlated with the densities of either GI or TA, but were positively correlated with the densities of EN and surviving neurons in some regions. (1) NFT were the most widespread tau-immunoreactive pathology in PSP being distributed randomly in subcortical regions and in regular clusters in cortical regions, (2) GI and TA were more localized and exhibited a regular pattern of clustering in subcortical regions, and (3) neuronal and glial cell pathologies were not spatially correlated. © 2012 Springer-Verlag.

AB - Progressive supranuclear palsy (PSP) is characterized neuropathologically by neuronal loss, gliosis, and the presence of tau-immunoreactive neuronal and glial cell inclusions affecting subcortical and some cortical regions. The objectives of this study were to determine (1) the spatial patterns of the tau-immunoreactive pathology, viz., neurofibrillary tangles (NFT), oligodendroglial inclusions (GI), tufted astrocytes (TA), and Alzheimer's disease-type neuritic plaques (NP) in PSP and (2) to investigate the spatial correlations between the histological features. Post-mortem material of cortical and subcortical regions of eight PSP cases was studied. Spatial pattern analysis was applied to the NFT, GI, TA, NP, abnormally enlarged neurons (EN), surviving neurons, and glial cells. NFT, GI, and TA were distributed either at random or in regularly distributed clusters. The EN and NP were mainly randomly distributed. Clustering of NFT and EN was more frequent in the cortex and subcortical regions, respectively. Variations in NFT density were not spatially correlated with the densities of either GI or TA, but were positively correlated with the densities of EN and surviving neurons in some regions. (1) NFT were the most widespread tau-immunoreactive pathology in PSP being distributed randomly in subcortical regions and in regular clusters in cortical regions, (2) GI and TA were more localized and exhibited a regular pattern of clustering in subcortical regions, and (3) neuronal and glial cell pathologies were not spatially correlated. © 2012 Springer-Verlag.

KW - neurofibrillary tangle (NFT)

KW - oligodendroglial inclusion (GI)

KW - progressive supranuclear palsy (PSP)

KW - spatial pattern

KW - tufted astrocyte (TA)

UR - http://www.scopus.com/inward/record.url?scp=84879694314&partnerID=8YFLogxK

U2 - 10.1007/s10072-012-1006-0

DO - 10.1007/s10072-012-1006-0

M3 - Article

VL - 34

SP - 337

EP - 344

JO - Neurological Sciences

T2 - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 3

ER -