Specific pH‐responsive folate‐conjugate microgels designed for antitumor therapy

Leyre Pérez-Álvarez, Virginia Sáez-Martínez, Estíbaliz Hernaez, M. Herrero, Issa Katime

Research output: Contribution to journalArticlepeer-review


Colloidal nanosized folate-conjugated hydrogels for targeted chemotherapy were prepared via a versatile and efficient postsynthetic modification pathway starting from P(NPA-co-NIPAM). The modifications included the introduction of 4-methylpyridine as pH-sensitive pendant groups and the conjugation of folic acid to the microgel network. The microgels showed a specific swelling at pH?<?6 (endosomes) as judged by DLS studies varying the external pH. The relative composition of the microgels shows a clear influence on the pH volume transition shifting. The potential of the microgels for anticancer drug release at pH?=?5.0 was confirmed. Therefore, they are a promising targeting carrier for improved anticancer chemotherapy.
Original languageEnglish
Pages (from-to)467-477
Number of pages11
JournalMacromolecular Chemistry and Physics
Issue number6
Publication statusPublished - 25 Mar 2009


  • folic acid
  • microgels
  • NMR
  • NPA
  • pH-responsive


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