Spray drying lactoferrin produces inhalable antimicrobial particles

W. Oguejiofor, L.J. Marshall, R. Price, J. Shur

Research output: Contribution to journalConference abstract

Abstract

The use of antimicrobial peptides and proteins as potential therapeutic agents in the management of multi-drug resistant infections is considered an attractive concept especially since such compounds should theoretically have low immunogenicity, high bioavailability with negligible toxicity. In this study we investigated the potential of developing a dry powder inhaler formulation of lactoferrin (a multifunctional iron binding protein). To achieve this, the protein was spray dried from a water only feedstock with suitably adjusted spray drying parameters. The particle size, degree of crystallinity, moisture content and yield of the spray dried powders along with the minimum bactericidal concentration (MBC) against Pseudomonas aeruginosa strain PAO1, were assessed. Dry powder inhaler formulations were prepared, and in vitro assessment studies using the multistage impinger were carried out to assess the aerosolisation performance of the formulations. Data obtained indicate that spray dried lactoferrin retains activity against biofilms and may be successfully employed in the treatment of chronic airway infections.
Original languageEnglish
Article number76
Pages (from-to)A259
Number of pages1
JournalJournal of aerosol medicine and pulmonary drug delivery
Volume26
Issue number4
Publication statusPublished - Aug 2013
EventAerosol Society drug delivery to the lungs 22 - Edinburgh International Conference Centre, Edinburgh, United Kingdom
Duration: 7 Oct 20119 Dec 2011

Bibliographical note

Abstracts from The Aerosol Society Drug Delivery to the Lungs 22, Edinburgh International Conference Centre, Edinburgh, Scotland, UK
December 7–9, 2011. Journal of Aerosol Medicine and Pulmonary Drug Delivery. Jul 2013, 26(4): A-1-A-27.

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