Symmetric decomposition of Mueller matrices reveals a new parametric space for polarimetric assistance in colon cancer histopathology

Deyan Ivanov, Viktor Dremin, Ekaterina Borisova, Alexander Bykov, Igor Meglinski, Tatiana Novikova, Razvigor Ossikovski, Jessica C. Ramella-Roman, Hui Ma (Editor), I. Alex Vitkin (Editor), Daniel S. Elson (Editor), Tatiana Novikova

Research output: Contribution to journalConference articlepeer-review


Tissue polarimetry could be identified as a complementary optical and non-invasive technique to assist the gold standard histopathology analysis of tissue. In general, polarimetric diagnostics is based on tracing different polarimetric responses (including light depolarization) in tissue zones with structure altered by the benign and pre/cancerous formations. In this manuscript, both healthy and malignant tissue zones of a thick formalin-fixed colon specimen were used for Mueller matrix measurements. Additionally, two more Mueller matrices from Monte Carlo simulation and tissue mimicking phantom were also evaluated, in order to assess polarimetric char- acterization and modeling of turbid media. Symmetric decomposition algorithm of Mueller matrices developed in house was adopted to extract both polarization and depolarization properties, encoded in the Mueller matrix elements. The decomposition products allowed to reveal important information about the internal tissue struc- ture and morphology. The depolarization and polarization parameters were found to follow the particular trends that depend on a choice of parametric space.
Original languageEnglish
Article number1164614
JournalProceedings of SPIE - International Society for Optical Engineering
Publication statusPublished - 5 Mar 2021
EventSPIE BIOS 2021 -
Duration: 6 Mar 202112 Mar 2021

Bibliographical note

Copyright 2021 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.


Dive into the research topics of 'Symmetric decomposition of Mueller matrices reveals a new parametric space for polarimetric assistance in colon cancer histopathology'. Together they form a unique fingerprint.

Cite this