Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

C. J. Mable; L. A. Fielding; M. J. Derry; O. O. Mykhaylyk; P. Chambon; S. P. Armes

doi:10.1039/c7sc04788f

Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

C. J. Mable, L. A. Fielding, M. J. Derry, O. O. Mykhaylyk, P. Chambon, S. P. Armes

Research output: Contribution to journal › Article › peer-review

Abstract

A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.

Original language	English
Pages (from-to)	1454-1463
Journal	Chemical Science
Volume	9
Issue number	6
Early online date	13 Dec 2017
DOIs	https://doi.org/10.1039/c7sc04788f
Publication status	Published - Dec 2018

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Synthesis and pH-responsive dissociation
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title = "Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution",

abstract = "A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.",

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AU - Mable, C. J.

AU - Fielding, L. A.

AU - Derry, M. J.

AU - Mykhaylyk, O. O.

AU - Chambon, P.

AU - Armes, S. P.

N1 - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

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N2 - A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.

AB - A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.

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Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

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