Systemic inflammatory impact of periodontitis on acute coronary syndrome

Cecilia Widén; Helene Holmer; Michael Coleman; Marian Tudor; Ola Ohlsson; Susanna Sättlin; Stefan Renvert; Goesta Rutger Persson

doi:10.1111/jcpe.12540

Systemic inflammatory impact of periodontitis on acute coronary syndrome

Cecilia Widén^*, Helene Holmer, Michael Coleman, Marian Tudor, Ola Ohlsson, Susanna Sättlin, Stefan Renvert, Goesta Rutger Persson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity. Material and Methods: In a case–control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology. Results: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p

Original language	English
Pages (from-to)	713-719
Number of pages	7
Journal	Journal of Clinical Periodontology
Volume	43
Issue number	9
Early online date	2 Jul 2016
DOIs	https://doi.org/10.1111/jcpe.12540
Publication status	Published - Sep 2016

Bibliographical note

This is the peer reviewed version of the following article: Widén, C., Holmer, H., Coleman, M., Tudor, M., Ohlsson, O., Sättlin, S., ... Persson, G. R. (2016). Systemic inflammatory impact of periodontitis on acute coronary syndrome. Journal of Clinical Periodontology, 43(9), 713-719, which has been published in final form at http://dx.doi.org/10.1111/jcpe.12540. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

Keywords

cardiovascular disease
cytokines
hs-CRP
human
oral disease
serum
VEGF

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10.1111/jcpe.12540

Systemic inflammatory impact of periodontitis on acute coronary syndrome
This is the peer reviewed version of the following article: Widén, C., Holmer, H., Coleman, M., Tudor, M., Ohlsson, O., Sättlin, S., ... Persson, G. R. (2016). Systemic inflammatory impact of periodontitis on acute coronary syndrome. Journal of Clinical Periodontology, 43(9), 713-719, which has been published in final form at http://dx.doi.org/10.1111/jcpe.12540. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Accepted author manuscript, 287 KB

http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12540/abstract

Cite this

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title = "Systemic inflammatory impact of periodontitis on acute coronary syndrome",

abstract = "Aim: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity. Material and Methods: In a case–control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology. Results: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p ",

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author = "Cecilia Wid{\'e}n and Helene Holmer and Michael Coleman and Marian Tudor and Ola Ohlsson and Susanna S{\"a}ttlin and Stefan Renvert and Persson, {Goesta Rutger}",

note = "This is the peer reviewed version of the following article: Wid{\'e}n, C., Holmer, H., Coleman, M., Tudor, M., Ohlsson, O., S{\"a}ttlin, S., ... Persson, G. R. (2016). Systemic inflammatory impact of periodontitis on acute coronary syndrome. Journal of Clinical Periodontology, 43(9), 713-719, which has been published in final form at http://dx.doi.org/10.1111/jcpe.12540. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving ",

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AU - Ohlsson, Ola

AU - Sättlin, Susanna

AU - Renvert, Stefan

AU - Persson, Goesta Rutger

N1 - This is the peer reviewed version of the following article: Widén, C., Holmer, H., Coleman, M., Tudor, M., Ohlsson, O., Sättlin, S., ... Persson, G. R. (2016). Systemic inflammatory impact of periodontitis on acute coronary syndrome. Journal of Clinical Periodontology, 43(9), 713-719, which has been published in final form at http://dx.doi.org/10.1111/jcpe.12540. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

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N2 - Aim: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity. Material and Methods: In a case–control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology. Results: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p

AB - Aim: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity. Material and Methods: In a case–control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology. Results: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p

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Systemic inflammatory impact of periodontitis on acute coronary syndrome

Abstract

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Keywords

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