Systemic inflammatory impact of periodontitis on acute coronary syndrome

Cecilia Widén*, Helene Holmer, Michael Coleman, Marian Tudor, Ola Ohlsson, Susanna Sättlin, Stefan Renvert, Goesta Rutger Persson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aim: A causative relationship between acute coronary syndrome (ACS) and periodontitis has yet to be defined. The aim of this study was to assess differences in levels of serum cytokines between individuals with or without ACS or periodontal comorbidity. Material and Methods: In a case–control study, individuals with ACS (78 individuals, 10.3% females) and matching healthy controls (78 individuals, 28.2% females) were included. Medical and dental examinations were performed to diagnose ACS and periodontitis. Serum levels of cytokines were assessed, using Luminex technology. Results: A diagnosis of periodontitis in the ACS and control group was diagnosed in 52.6% and 12.8% of the individuals, respectively. The unadjusted odds-ratio that individuals with ACS also had periodontitis was 7.5 (95% CI: 3.4, 16.8, p 

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalJournal of Clinical Periodontology
Issue number9
Early online date2 Jul 2016
Publication statusPublished - Sept 2016

Bibliographical note

This is the peer reviewed version of the following article: Widén, C., Holmer, H., Coleman, M., Tudor, M., Ohlsson, O., Sättlin, S., ... Persson, G. R. (2016). Systemic inflammatory impact of periodontitis on acute coronary syndrome. Journal of Clinical Periodontology, 43(9), 713-719, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving


  • cardiovascular disease
  • cytokines
  • hs-CRP
  • human
  • oral disease
  • serum
  • VEGF


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