Temporal lobe pathology in neurodegenerative disease

a comparative study of eight disorders with special reference to the hippocampus

Richard Armstrong

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

The temporal lobe is a major site of pathology in a number of neurodegenerative diseases. In this chapter, the densities of the characteristic pathological lesions in various regions of the temporal lobe were compared in eight neurodegenerative disorders, viz., Alzheimer’s disease (AD), Down’s syndrome (DS), dementia with Lewy bodies (DLB), Pick’s disease (PiD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), sporadic Creutzfeldt-Jakob disease (sCJD), and neuronal intermediate filament inclusion disease (NIFID). Temporal lobe pathology was observed in all of these disorders most notably in AD, DS, PiD, sCJD, and NIFID. The regions of the temporal lobe affected by the pathology, however, varied between disorders. In AD and DS, the greatest densities of ?-amyloid (A?) deposits were recorded in cortical regions adjacent to the hippocampus (HC), DS exhibiting greater densities of A? deposits than AD. Similarly, in sCJD, greatest densities of prion protein (PrPsc) deposits were recorded in cortical areas of the temporal lobe. In AD and PiD, significant densities of neurofibrillary tangles (NFT) and Pick bodies (PB) respectively were present in sector CA1 of the HC while in CBD, the greatest densities of tau-immunoreactive neuronal cytoplasmic inclusions (NCI) were present in the parahippocampal gyrus (PHG). Particularly high densities of PB were present in the DG in PiD, whereas NFT in AD and Lewy bodies (LB) in DLB were usually absent in this region. These data confirm that the temporal lobe is an important site of pathology in the disorders studied regardless of their molecular ‘signature’. However, disorders differ in the extent to which the pathology spreads to affect the HC which may account for some of the observed differences in clinical dementia.
Original languageEnglish
Title of host publicationHorizons in neuroscience research
EditorsAndres Costa, Eugenio Villalba
Place of PublicationHappauge
PublisherNova science
Pages95-118
Number of pages23
Volume7
ISBN (Print)978-1-61942-188-2
Publication statusPublished - 2012

Fingerprint

Temporal Lobe
Neurodegenerative Diseases
Hippocampus
Pick Disease of the Brain
Alzheimer Disease
Pathology
Down Syndrome
Lewy Body Disease
Neurofibrillary Tangles
Intermediate Filaments
Cytomegalovirus Infections
Dementia
Progressive Supranuclear Palsy
Lewy Bodies
Parahippocampal Gyrus
Inclusion Bodies
Amyloid Plaques
Sporadic Creutzfeldt-Jakob Disease

Cite this

Armstrong, R. (2012). Temporal lobe pathology in neurodegenerative disease: a comparative study of eight disorders with special reference to the hippocampus. In A. Costa, & E. Villalba (Eds.), Horizons in neuroscience research (Vol. 7, pp. 95-118). Happauge: Nova science.
Armstrong, Richard. / Temporal lobe pathology in neurodegenerative disease : a comparative study of eight disorders with special reference to the hippocampus. Horizons in neuroscience research. editor / Andres Costa ; Eugenio Villalba. Vol. 7 Happauge : Nova science, 2012. pp. 95-118
@inbook{2666a8c366e8401b88ae7f95f5e76e67,
title = "Temporal lobe pathology in neurodegenerative disease: a comparative study of eight disorders with special reference to the hippocampus",
abstract = "The temporal lobe is a major site of pathology in a number of neurodegenerative diseases. In this chapter, the densities of the characteristic pathological lesions in various regions of the temporal lobe were compared in eight neurodegenerative disorders, viz., Alzheimer’s disease (AD), Down’s syndrome (DS), dementia with Lewy bodies (DLB), Pick’s disease (PiD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), sporadic Creutzfeldt-Jakob disease (sCJD), and neuronal intermediate filament inclusion disease (NIFID). Temporal lobe pathology was observed in all of these disorders most notably in AD, DS, PiD, sCJD, and NIFID. The regions of the temporal lobe affected by the pathology, however, varied between disorders. In AD and DS, the greatest densities of ?-amyloid (A?) deposits were recorded in cortical regions adjacent to the hippocampus (HC), DS exhibiting greater densities of A? deposits than AD. Similarly, in sCJD, greatest densities of prion protein (PrPsc) deposits were recorded in cortical areas of the temporal lobe. In AD and PiD, significant densities of neurofibrillary tangles (NFT) and Pick bodies (PB) respectively were present in sector CA1 of the HC while in CBD, the greatest densities of tau-immunoreactive neuronal cytoplasmic inclusions (NCI) were present in the parahippocampal gyrus (PHG). Particularly high densities of PB were present in the DG in PiD, whereas NFT in AD and Lewy bodies (LB) in DLB were usually absent in this region. These data confirm that the temporal lobe is an important site of pathology in the disorders studied regardless of their molecular ‘signature’. However, disorders differ in the extent to which the pathology spreads to affect the HC which may account for some of the observed differences in clinical dementia.",
author = "Richard Armstrong",
year = "2012",
language = "English",
isbn = "978-1-61942-188-2",
volume = "7",
pages = "95--118",
editor = "Andres Costa and Eugenio Villalba",
booktitle = "Horizons in neuroscience research",
publisher = "Nova science",

}

Armstrong, R 2012, Temporal lobe pathology in neurodegenerative disease: a comparative study of eight disorders with special reference to the hippocampus. in A Costa & E Villalba (eds), Horizons in neuroscience research. vol. 7, Nova science, Happauge, pp. 95-118.

Temporal lobe pathology in neurodegenerative disease : a comparative study of eight disorders with special reference to the hippocampus. / Armstrong, Richard.

Horizons in neuroscience research. ed. / Andres Costa; Eugenio Villalba. Vol. 7 Happauge : Nova science, 2012. p. 95-118.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

TY - CHAP

T1 - Temporal lobe pathology in neurodegenerative disease

T2 - a comparative study of eight disorders with special reference to the hippocampus

AU - Armstrong, Richard

PY - 2012

Y1 - 2012

N2 - The temporal lobe is a major site of pathology in a number of neurodegenerative diseases. In this chapter, the densities of the characteristic pathological lesions in various regions of the temporal lobe were compared in eight neurodegenerative disorders, viz., Alzheimer’s disease (AD), Down’s syndrome (DS), dementia with Lewy bodies (DLB), Pick’s disease (PiD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), sporadic Creutzfeldt-Jakob disease (sCJD), and neuronal intermediate filament inclusion disease (NIFID). Temporal lobe pathology was observed in all of these disorders most notably in AD, DS, PiD, sCJD, and NIFID. The regions of the temporal lobe affected by the pathology, however, varied between disorders. In AD and DS, the greatest densities of ?-amyloid (A?) deposits were recorded in cortical regions adjacent to the hippocampus (HC), DS exhibiting greater densities of A? deposits than AD. Similarly, in sCJD, greatest densities of prion protein (PrPsc) deposits were recorded in cortical areas of the temporal lobe. In AD and PiD, significant densities of neurofibrillary tangles (NFT) and Pick bodies (PB) respectively were present in sector CA1 of the HC while in CBD, the greatest densities of tau-immunoreactive neuronal cytoplasmic inclusions (NCI) were present in the parahippocampal gyrus (PHG). Particularly high densities of PB were present in the DG in PiD, whereas NFT in AD and Lewy bodies (LB) in DLB were usually absent in this region. These data confirm that the temporal lobe is an important site of pathology in the disorders studied regardless of their molecular ‘signature’. However, disorders differ in the extent to which the pathology spreads to affect the HC which may account for some of the observed differences in clinical dementia.

AB - The temporal lobe is a major site of pathology in a number of neurodegenerative diseases. In this chapter, the densities of the characteristic pathological lesions in various regions of the temporal lobe were compared in eight neurodegenerative disorders, viz., Alzheimer’s disease (AD), Down’s syndrome (DS), dementia with Lewy bodies (DLB), Pick’s disease (PiD), corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), sporadic Creutzfeldt-Jakob disease (sCJD), and neuronal intermediate filament inclusion disease (NIFID). Temporal lobe pathology was observed in all of these disorders most notably in AD, DS, PiD, sCJD, and NIFID. The regions of the temporal lobe affected by the pathology, however, varied between disorders. In AD and DS, the greatest densities of ?-amyloid (A?) deposits were recorded in cortical regions adjacent to the hippocampus (HC), DS exhibiting greater densities of A? deposits than AD. Similarly, in sCJD, greatest densities of prion protein (PrPsc) deposits were recorded in cortical areas of the temporal lobe. In AD and PiD, significant densities of neurofibrillary tangles (NFT) and Pick bodies (PB) respectively were present in sector CA1 of the HC while in CBD, the greatest densities of tau-immunoreactive neuronal cytoplasmic inclusions (NCI) were present in the parahippocampal gyrus (PHG). Particularly high densities of PB were present in the DG in PiD, whereas NFT in AD and Lewy bodies (LB) in DLB were usually absent in this region. These data confirm that the temporal lobe is an important site of pathology in the disorders studied regardless of their molecular ‘signature’. However, disorders differ in the extent to which the pathology spreads to affect the HC which may account for some of the observed differences in clinical dementia.

UR - https://www.novapublishers.com/catalog/product_info.php?products_id=35295

M3 - Chapter (peer-reviewed)

SN - 978-1-61942-188-2

VL - 7

SP - 95

EP - 118

BT - Horizons in neuroscience research

A2 - Costa, Andres

A2 - Villalba, Eugenio

PB - Nova science

CY - Happauge

ER -

Armstrong R. Temporal lobe pathology in neurodegenerative disease: a comparative study of eight disorders with special reference to the hippocampus. In Costa A, Villalba E, editors, Horizons in neuroscience research. Vol. 7. Happauge: Nova science. 2012. p. 95-118