The detection of kinin activity in contact lens wear

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

Many factors can be, and have been, attributed to the appearance of complications in lens wear, but the greatest is associated with deposition. Reduced acuity, irritation and inflammatory responses are often referred to as adverse reactions arising as a result of deposition. In this study, particular attention was paid to the potential role of adsorbed proteins in activating, mediating and/or stimulating a host immune response, i.e., the hypothesis that the adsorption of certain proteins from the tears and ocular surfaces may actively affect successful lens wear. In particular, the purpose of this study was to investigate the presence of a group of proteins previously undiscovered in the ocular environment. The intention was to target a family of proteins/glycoproteins that have become prominent recently in a variety of inflammatory responses and disorders at many other mucosal associated sites around the body, e.g. in nasal rhinitis and in joint inflammation. The protein cascade in question is the kinin family of inflammatory mediators. The aim was to investigate their presence in the ocular environment, specifically in relation to contact lens wear, and consequently assess the implications of their discovery. High molecular weight kininogen (HMWK), with its central role in kinin responses, was investigated initially as the marker of kinin activity, with subsequent members examined thereafter.
Original languageEnglish
Title of host publicationThe detection of kinin activity in contact lens wear
Subtitle of host publicationbasic science and clinical relevance Part B
EditorsDavid A. Sullivan, Michael E. Stern, Kazuo Tsubota, Darlene A. Dartt, Rose M. Sullivan, B. Britt Bromberg
Place of PublicationNew York (US)
PublisherSpringer
Pages961-966
Number of pages6
ISBN (Electronic)978-1-4615-0717-8
ISBN (Print)978-1-4613-5208-2
DOIs
Publication statusPublished - 1 Jan 2002

Publication series

NameAdvances in experimental medicine and biology
PublisherSpringer
Volume506
ISSN (Print)0065-2598

Fingerprint

Kinins
Contact Lenses
Lenses
Proteins
High Molecular Weight Kininogens
Rhinitis
Nose
Adsorption
Glycoproteins
Joints
Inflammation

Keywords

  • detection
  • kinin activity
  • contact lens wear

Cite this

Mann, A. M., & Tighe, B. J. (2002). The detection of kinin activity in contact lens wear. In D. A. Sullivan, M. E. Stern, K. Tsubota, D. A. Dartt, R. M. Sullivan, & B. B. Bromberg (Eds.), The detection of kinin activity in contact lens wear: basic science and clinical relevance Part B (pp. 961-966). (Advances in experimental medicine and biology; Vol. 506). New York (US): Springer. https://doi.org/10.1007/978-1-4615-0717-8_34
Mann, Aisling M. ; Tighe, Brian J. / The detection of kinin activity in contact lens wear. The detection of kinin activity in contact lens wear: basic science and clinical relevance Part B. editor / David A. Sullivan ; Michael E. Stern ; Kazuo Tsubota ; Darlene A. Dartt ; Rose M. Sullivan ; B. Britt Bromberg. New York (US) : Springer, 2002. pp. 961-966 (Advances in experimental medicine and biology).
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Mann, AM & Tighe, BJ 2002, The detection of kinin activity in contact lens wear. in DA Sullivan, ME Stern, K Tsubota, DA Dartt, RM Sullivan & BB Bromberg (eds), The detection of kinin activity in contact lens wear: basic science and clinical relevance Part B. Advances in experimental medicine and biology, vol. 506, Springer, New York (US), pp. 961-966. https://doi.org/10.1007/978-1-4615-0717-8_34

The detection of kinin activity in contact lens wear. / Mann, Aisling M.; Tighe, Brian J.

The detection of kinin activity in contact lens wear: basic science and clinical relevance Part B. ed. / David A. Sullivan; Michael E. Stern; Kazuo Tsubota; Darlene A. Dartt; Rose M. Sullivan; B. Britt Bromberg. New York (US) : Springer, 2002. p. 961-966 (Advances in experimental medicine and biology; Vol. 506).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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AB - Many factors can be, and have been, attributed to the appearance of complications in lens wear, but the greatest is associated with deposition. Reduced acuity, irritation and inflammatory responses are often referred to as adverse reactions arising as a result of deposition. In this study, particular attention was paid to the potential role of adsorbed proteins in activating, mediating and/or stimulating a host immune response, i.e., the hypothesis that the adsorption of certain proteins from the tears and ocular surfaces may actively affect successful lens wear. In particular, the purpose of this study was to investigate the presence of a group of proteins previously undiscovered in the ocular environment. The intention was to target a family of proteins/glycoproteins that have become prominent recently in a variety of inflammatory responses and disorders at many other mucosal associated sites around the body, e.g. in nasal rhinitis and in joint inflammation. The protein cascade in question is the kinin family of inflammatory mediators. The aim was to investigate their presence in the ocular environment, specifically in relation to contact lens wear, and consequently assess the implications of their discovery. High molecular weight kininogen (HMWK), with its central role in kinin responses, was investigated initially as the marker of kinin activity, with subsequent members examined thereafter.

KW - detection

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Mann AM, Tighe BJ. The detection of kinin activity in contact lens wear. In Sullivan DA, Stern ME, Tsubota K, Dartt DA, Sullivan RM, Bromberg BB, editors, The detection of kinin activity in contact lens wear: basic science and clinical relevance Part B. New York (US): Springer. 2002. p. 961-966. (Advances in experimental medicine and biology). https://doi.org/10.1007/978-1-4615-0717-8_34