The effect of simulated cataract light scatter on retinal vessel oximetry

Sunni R. Patel*, Chris Hudson, John G. Flanagan, Rebekka Heitmar

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalExperimental Eye Research
Volume116
Early online date19 Sep 2013
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Retinal Vessels
Oximetry
Cataract
Light
Photography
Polystyrenes
Pupil
Intraocular Pressure
Microspheres
Lenses
Plastics
Germany
Dilatation
Oxygen
Blood Pressure

Bibliographical note

NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI http://dx.doi.org/10.1016/j.exer.2013.09.004

Keywords

  • cataract models
  • extraneous factors
  • light scatter
  • retinal oximetry
  • retinal oxygenation

Cite this

Patel, Sunni R. ; Hudson, Chris ; Flanagan, John G. ; Heitmar, Rebekka. / The effect of simulated cataract light scatter on retinal vessel oximetry. In: Experimental Eye Research. 2013 ; Vol. 116. pp. 185-189.
@article{087ce574a1144668973ca1d136eb6d1d,
title = "The effect of simulated cataract light scatter on retinal vessel oximetry",
abstract = "To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004{\%}) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004{\%} condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. {\circledC} 2013 Elsevier Ltd.",
keywords = "cataract models, extraneous factors, light scatter, retinal oximetry, retinal oxygenation",
author = "Patel, {Sunni R.} and Chris Hudson and Flanagan, {John G.} and Rebekka Heitmar",
note = "NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI http://dx.doi.org/10.1016/j.exer.2013.09.004",
year = "2013",
month = "11",
doi = "10.1016/j.exer.2013.09.004",
language = "English",
volume = "116",
pages = "185--189",
journal = "Experimental Eye Research",
issn = "0014-4835",
publisher = "Academic Press Inc.",

}

The effect of simulated cataract light scatter on retinal vessel oximetry. / Patel, Sunni R.; Hudson, Chris; Flanagan, John G.; Heitmar, Rebekka.

In: Experimental Eye Research, Vol. 116, 11.2013, p. 185-189.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of simulated cataract light scatter on retinal vessel oximetry

AU - Patel, Sunni R.

AU - Hudson, Chris

AU - Flanagan, John G.

AU - Heitmar, Rebekka

N1 - NOTICE: this is the author’s version of a work that was accepted for publication in Experimental eye research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Patel, SR, Hudson, C, Flanagan, JG & Heitmar, R, 'The effect of simulated cataract light scatter on retinal vessel oximetry' Experimental eye research, vol. 116 (2013) DOI http://dx.doi.org/10.1016/j.exer.2013.09.004

PY - 2013/11

Y1 - 2013/11

N2 - To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

AB - To assess the impact of light scatter, similar to that introduced by cataract on retinal vessel blood oxygen saturation measurements using poly-bead solutions of varying concentrations. Eight healthy, young, non-smoking individuals were enrolled for this study. All subjects underwent digital blood pressure measurements, assessment of non-contact intraocular pressure, pupil dilation and retinal vessel oximetry using dual wavelength photography (Oximetry Module, Imedos Systems, Germany). To simulate light scatter, cells comprising a plastic collar and two plano lenses were filled with solutions of differing concentrations (0.001, 0.002 and 0.004%) of polystyrene microspheres (Polysciences Inc., USA). The adopted light scatter model showed an artifactual increase in venous optical density ratio (p=0.036), with the 0.004% condition producing significantly higher venous optical density ratio values when compared to images without a cell in place. Spectrophotometric analysis, and thus retinal vessel oximetry of the retinal vessels, is altered by artificial light scatter. © 2013 Elsevier Ltd.

KW - cataract models

KW - extraneous factors

KW - light scatter

KW - retinal oximetry

KW - retinal oxygenation

UR - http://www.scopus.com/inward/record.url?scp=84884706142&partnerID=8YFLogxK

U2 - 10.1016/j.exer.2013.09.004

DO - 10.1016/j.exer.2013.09.004

M3 - Article

C2 - 24056207

VL - 116

SP - 185

EP - 189

JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

ER -