The flavonoid galangin inhibits the L1 metallo-β-lactamase from Stenotrophomonas maltophilia

Brian J. Denny*, Peter A. Lambert, Patrick W J West

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The flavonoid galangin inhibits the partially purified metallo-β-lactamase from Stenotrophomonas maltophilia. The effect was not reversed by the addition of ZnCl2 suggesting that the inhibitory effect is not related to metal chelation. The flavonoid quercetin also has some inhibitory effect against the enzyme. Using the crystal structure of the enzyme, a molecular modelling study predicts a possible orientation of galangin at the active site of the enzyme.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalFEMS Microbiology Letters
Volume208
Issue number1
DOIs
Publication statusPublished - 19 Feb 2002

Keywords

  • Flavonoid
  • Galangin
  • Metallo-β-lactamase
  • Molecular modelling
  • Stenotrophomonas maltophilia

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