The influence of mouse Ped gene expression on postnatal development

Adam Watkins, Adrian Wilkins, Clive Osmond, Carol M. Warner, Martina Comiskey, Mark Hanson, Tom P. Fleming

Research output: Contribution to journalArticle

Abstract

The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P
Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalJournal of Physiology
Volume571
Early online date3 Nov 2003
DOIs
Publication statusPublished - 15 Feb 2006

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