The influence of mouse Ped gene expression on postnatal development

Adam Watkins, Adrian Wilkins, Clive Osmond, Carol M. Warner, Martina Comiskey, Mark Hanson, Tom P. Fleming

Research output: Contribution to journalArticle

Abstract

The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P
Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalJournal of Physiology
Volume571
Early online date3 Nov 2003
DOIs
Publication statusPublished - 15 Feb 2006

Fingerprint

Embryonic Development
Gene Expression
Blood Pressure
Congenic Mice
Phenotype
Proteins
Genes
Parturition
Growth

Cite this

Watkins, A., Wilkins, A., Osmond, C., Warner, C. M., Comiskey, M., Hanson, M., & Fleming, T. P. (2006). The influence of mouse Ped gene expression on postnatal development. Journal of Physiology, 571, 211-220. https://doi.org/10.1113/jphysiol.2005.099192
Watkins, Adam ; Wilkins, Adrian ; Osmond, Clive ; Warner, Carol M. ; Comiskey, Martina ; Hanson, Mark ; Fleming, Tom P. / The influence of mouse Ped gene expression on postnatal development. In: Journal of Physiology. 2006 ; Vol. 571. pp. 211-220.
@article{b8ca24a969514565a64b34360df9b765,
title = "The influence of mouse Ped gene expression on postnatal development",
abstract = "The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P",
author = "Adam Watkins and Adrian Wilkins and Clive Osmond and Warner, {Carol M.} and Martina Comiskey and Mark Hanson and Fleming, {Tom P.}",
year = "2006",
month = "2",
day = "15",
doi = "10.1113/jphysiol.2005.099192",
language = "English",
volume = "571",
pages = "211--220",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",

}

Watkins, A, Wilkins, A, Osmond, C, Warner, CM, Comiskey, M, Hanson, M & Fleming, TP 2006, 'The influence of mouse Ped gene expression on postnatal development', Journal of Physiology, vol. 571, pp. 211-220. https://doi.org/10.1113/jphysiol.2005.099192

The influence of mouse Ped gene expression on postnatal development. / Watkins, Adam; Wilkins, Adrian; Osmond, Clive; Warner, Carol M.; Comiskey, Martina; Hanson, Mark; Fleming, Tom P.

In: Journal of Physiology, Vol. 571, 15.02.2006, p. 211-220.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The influence of mouse Ped gene expression on postnatal development

AU - Watkins, Adam

AU - Wilkins, Adrian

AU - Osmond, Clive

AU - Warner, Carol M.

AU - Comiskey, Martina

AU - Hanson, Mark

AU - Fleming, Tom P.

PY - 2006/2/15

Y1 - 2006/2/15

N2 - The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P

AB - The Ped (preimplantation embryo development) gene, whose product is Qa-2 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice that express Qa-2 protein compared with mice with an absence of Qa-2 protein (Ped slow phenotype). In the current study, we have used two congenic mouse strains differentially expressing the Ped gene, strain B6.K1 (Ped slow; Qa-2 negative) and strain B6.K2 (Ped fast; Qa-2 positive), to investigate the effects of Ped gene expression on postnatal growth profiles, systolic blood pressure and adult organ allometry. At birth, B6.K1 mice were moderately lighter than B6.K2 mice. B6.K1 mice became heavier during postnatal life (P

UR - http://www.scopus.com/inward/record.url?scp=33645866472&partnerID=8YFLogxK

UR - http://jp.physoc.org/content/571/1/211

U2 - 10.1113/jphysiol.2005.099192

DO - 10.1113/jphysiol.2005.099192

M3 - Article

AN - SCOPUS:33645866472

VL - 571

SP - 211

EP - 220

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

ER -

Watkins A, Wilkins A, Osmond C, Warner CM, Comiskey M, Hanson M et al. The influence of mouse Ped gene expression on postnatal development. Journal of Physiology. 2006 Feb 15;571:211-220. https://doi.org/10.1113/jphysiol.2005.099192