The relationship between senile plaques, neurofibrillary tangles and amyloid (A4) deposits in Alzheimer’s disease: A Principal Components Analysis

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

A Principal Components Analysis (PCA) was carried out on the density of lesions revealed by different stains in a total of 47 brain regions from six elderly patients with Alzheimer’s disease (AD). The aim was to determine the relationships between the density of senile plaques (SP) revealed by the Glees and Gallyas stains and A4 deposits and between the plaques and neurofibrillary tangles (NFT) in the same brain region. The analysis indicated that the populations of plaques revealed by the Glees and Gallyas stains were closely related to the A4 protein deposits but none of the lesions were related to NFT. The data suggest: 1) that neocortical regions differ from the hippocampus in the relative development of A4 and NFT; the former having more A4 deposits and the latter more NFT and 2) that the processes that lead to the formation of SP and NFT occur independently of each other in the same brain region.
Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalNeuroscience Research Communications
Volume9
Issue number2
Publication statusPublished - 1991

Keywords

  • Alzheimer’s disease
  • principal components analysis
  • senile plaques
  • neurofibrillary tangles
  • A4 deposits

Fingerprint Dive into the research topics of 'The relationship between senile plaques, neurofibrillary tangles and amyloid (A4) deposits in Alzheimer’s disease: A Principal Components Analysis'. Together they form a unique fingerprint.

  • Cite this