The relationship of psychological variables and disease progression among long-term HIV-infected men

S. Thornton; M. Troop; A P Burgess; J. Button; R. Goodall; R. Flynn; BG Gazzard; J. Catalán; PJ Easterbrook

doi:10.1258/0956462001915165

The relationship of psychological variables and disease progression among long-term HIV-infected men

S. Thornton, M. Troop, A P Burgess, J. Button, R. Goodall, R. Flynn, BG Gazzard, J. Catalán, PJ Easterbrook

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the contribution of psychological factors to disease progression among long-term HIV-1 infected gay men. Participants completed self-report measures including coping strategies, life events, social support, personality and psychological morbidity and were followed clinically for up to 30 months. Cox proportional hazards survival analyses were carried out to CD4 < 200 × 106/l and AIDS-related complex (ARC) or AIDS diagnosis controlling for viral load, antiretroviral drug use and CD4 count. Only acceptance coping was a significant predictor of time to ARC or AIDS diagnosis: the risk of ARC or AIDS was almost 5 times greater for those scoring within the lowest tertile compared with those scoring in the highest tertile (HR = 4.7, 95% CI 1.8-12.3).

Original language	English
Pages (from-to)	734-742
Number of pages	9
Journal	International Journal of Std and Aids
Volume	11
Issue number	11
DOIs	https://doi.org/10.1258/0956462001915165
Publication status	Published - 1 Nov 2000

Keywords

HIV infection
disease progression
AIDS
gay men
psychological variables

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10.1258/0956462001915165

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abstract = "This study investigated the contribution of psychological factors to disease progression among long-term HIV-1 infected gay men. Participants completed self-report measures including coping strategies, life events, social support, personality and psychological morbidity and were followed clinically for up to 30 months. Cox proportional hazards survival analyses were carried out to CD4 < 200 × 106/l and AIDS-related complex (ARC) or AIDS diagnosis controlling for viral load, antiretroviral drug use and CD4 count. Only acceptance coping was a significant predictor of time to ARC or AIDS diagnosis: the risk of ARC or AIDS was almost 5 times greater for those scoring within the lowest tertile compared with those scoring in the highest tertile (HR = 4.7, 95% CI 1.8-12.3).",

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T1 - The relationship of psychological variables and disease progression among long-term HIV-infected men

AU - Thornton, S.

AU - Troop, M.

AU - Burgess, A P

AU - Button, J.

AU - Goodall, R.

AU - Flynn, R.

AU - Gazzard, BG

AU - Catalán, J.

AU - Easterbrook, PJ

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N2 - This study investigated the contribution of psychological factors to disease progression among long-term HIV-1 infected gay men. Participants completed self-report measures including coping strategies, life events, social support, personality and psychological morbidity and were followed clinically for up to 30 months. Cox proportional hazards survival analyses were carried out to CD4 < 200 × 106/l and AIDS-related complex (ARC) or AIDS diagnosis controlling for viral load, antiretroviral drug use and CD4 count. Only acceptance coping was a significant predictor of time to ARC or AIDS diagnosis: the risk of ARC or AIDS was almost 5 times greater for those scoring within the lowest tertile compared with those scoring in the highest tertile (HR = 4.7, 95% CI 1.8-12.3).

AB - This study investigated the contribution of psychological factors to disease progression among long-term HIV-1 infected gay men. Participants completed self-report measures including coping strategies, life events, social support, personality and psychological morbidity and were followed clinically for up to 30 months. Cox proportional hazards survival analyses were carried out to CD4 < 200 × 106/l and AIDS-related complex (ARC) or AIDS diagnosis controlling for viral load, antiretroviral drug use and CD4 count. Only acceptance coping was a significant predictor of time to ARC or AIDS diagnosis: the risk of ARC or AIDS was almost 5 times greater for those scoring within the lowest tertile compared with those scoring in the highest tertile (HR = 4.7, 95% CI 1.8-12.3).

KW - HIV infection

KW - disease progression

KW - AIDS

KW - gay men

KW - psychological variables

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DO - 10.1258/0956462001915165

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JO - International Journal of Std and Aids

JF - International Journal of Std and Aids

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ER -

The relationship of psychological variables and disease progression among long-term HIV-infected men

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