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The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration

  • Alex L Wilkinson
  • , Samuel Hulme
  • , James I Kennedy
  • , Emily R Mann
  • , Paul Horn
  • , Emma L Shepherd
  • , Kelvin Yin
  • , Marco Y W Zaki
  • , Gareth Hardisty
  • , Wei-Yu Lu
  • , Pia Rantakari
  • , David H Adams
  • , Marko Salmi
  • , Matthew Hoare
  • , Daniel A Patten
  • , Shishir Shetty
  • Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
  • University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK.
  • Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.
  • Centre for Inflammation Research, University of Edinburgh, Edinburgh EH8 9YL, UK.
  • MediCity Research Laboratory, University of Turku, Turku, Finland.
  • University of Cambridge, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  • Centre for Patient Reported Outcomes Research, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham, Birmingham, United Kingdom; National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, West Midlands, UK University, Birmingham, United Kingdom

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Biochemistry, Genetics and Molecular Biology

Immunology and Microbiology