The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

Mariia Borovkova*, Alexander Bykov, Alexey Popov, Angelo Pierangelo, Tatiana Novikova, Jens Pahnke, Igor Meglinski

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.

Original languageEnglish
Title of host publicationOptical Biopsy XVIII
Subtitle of host publicationToward Real-Time Spectroscopic Imaging and Diagnosis
EditorsRobert R. Alfano, Stavros G. Demos, Angela B. Seddon
PublisherSPIE
ISBN (Electronic)9781510632318
DOIs
Publication statusPublished - 21 Feb 2020
EventOptical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020 - San Francisco, United States
Duration: 2 Feb 20205 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11234
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020
CountryUnited States
CitySan Francisco
Period2/02/205/02/20

Bibliographical note

Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Keywords

  • Alzheimer's
  • Amyloid-ß plaque
  • Anisotropy
  • Depolarization
  • Scattering
  • Statistical analysis

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    Borovkova, M., Bykov, A., Popov, A., Pierangelo, A., Novikova, T., Pahnke, J., & Meglinski, I. (2020). The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease. In R. R. Alfano, S. G. Demos, & A. B. Seddon (Eds.), Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis [112340M] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11234). SPIE. https://doi.org/10.1117/12.2550795