The value of magnetoencephalography to guide electrode implantation in epilepsy

Zaloa Agirre-Arrizubieta, Ngoc J. Thai, Antonio Valentín, Paul L. Furlong, Stefano Seri*, Richard P. Selway, Robert D.C. Elwes, Gonzalo Alarcón

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

To investigate if Magnetoencephalography (MEG) can add non-redundant information to guide implantation sites for intracranial recordings (IR). The contribution of MEG to intracranial recording planning was evaluated in 12 consecutive patients assessed pre-surgically with MEG followed by IR. Primary outcome measures were the identification of focal seizure onset in IR and favorable surgical outcome. Outcome measures were compared to those of 12 patients matched for implantation type in whom non-invasive pre-surgical assessment suggested clear hypotheses for implantation (non-MEG group). In the MEG group, non-invasive assessment without MEG was inconclusive, and MEG was then used to further help identify implantation sites. In all MEG patients, at least one virtual MEG electrode generated suitable hypotheses for the location of implantations. No differences in outcome measures were found between non-MEG and MEG groups. Although the MEG group included more complex patients, it showed similar percentage of successful implantations as the non-MEG group. This suggests that MEG can contribute to identify implantation sites where standard methods failed. © 2013 Springer Science+Business Media New York.

Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalBrain Topography
Volume27
Issue number1
Early online date19 Nov 2013
DOIs
Publication statusPublished - Jan 2014

Keywords

  • beamformers
  • epilepsy surgery
  • epileptogenic zone
  • invasive recording
  • magnetic source imaging
  • magnetoencephalography

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    Agirre-Arrizubieta, Z., Thai, N. J., Valentín, A., Furlong, P. L., Seri, S., Selway, R. P., Elwes, R. D. C., & Alarcón, G. (2014). The value of magnetoencephalography to guide electrode implantation in epilepsy. Brain Topography, 27(1), 197-207. https://doi.org/10.1007/s10548-013-0330-x