Thiol redox homeostasis in neurodegenerative disease

Gethin J. McBean*, Mutay Aslan, Helen R. Griffiths, Rita C Torrão

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc- cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and glaucoma. The role of thiol disulphide oxidoreductases in providing neuroprotection is also discussed.

Original languageEnglish
Pages (from-to)186-194
Number of pages9
JournalRedox biology
Volume5
Early online date22 Apr 2015
DOIs
Publication statusPublished - Aug 2015

Bibliographical note

© 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Supported by the European Cooperation In Science and Technology (COST) Action BM1203, EU-ROS.

Keywords

  • cysteine
  • glutathione
  • thioredoxin
  • glutaredoxin
  • peroxiredoxin
  • neurodegenerative disease

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    McBean, G. J., Aslan, M., Griffiths, H. R., & Torrão, R. C. (2015). Thiol redox homeostasis in neurodegenerative disease. Redox biology, 5, 186-194. https://doi.org/10.1016/j.redox.2015.04.004