Tunable Ag@SiO2 core-shell nanocomposites for broad spectrum antibacterial applications

Mark A. Isaacs, Lee J. Durndell, Anthony C. Hilton, Luca Olivi, Christopher M.A. Parlett, Karen Wilson*, Adam F. Lee

*Corresponding author for this work

Research output: Contribution to journalArticle


Silica encapsulated silver nanoparticle core-shell nanocomposites of tunable dimensions were synthesised via a one-pot reverse microemulsion route to achieve controlled release of Ag+ ions for broad spectrum antibacterial application. Silver release rates and bactericidal efficacy against Gram-positive and Gram-negative bacteria, S. aureus and P. aeruginosa respectively, were inversely proportional to nanoparticle core diameter (3-8 nm) and silica shell (7-14 nm) thickness, and readily tuned through a facile hydrothermal etching protocol employing a PVP stabiliser to introduce mesoporosity.

Original languageEnglish
Pages (from-to)23342-23347
Number of pages6
JournalRSC advances
Issue number38
Publication statusPublished - 27 Apr 2017

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    Isaacs, M. A., Durndell, L. J., Hilton, A. C., Olivi, L., Parlett, C. M. A., Wilson, K., & Lee, A. F. (2017). Tunable Ag@SiO2 core-shell nanocomposites for broad spectrum antibacterial applications. RSC advances, 7(38), 23342-23347. https://doi.org/10.1039/c7ra03131a