Ultraviolet Light Responsive N‐Nitroso Polymers for Antibacterial Nitric Oxide Delivery

Yusheng Qiu, Taoran Zhao, Xin Lu, Qingchun Yuan, Sharon Gregg, René‐Ponce Nze, Bo Xiao

Research output: Contribution to journalArticlepeer-review


This study investigates the incorporation of active secondary amine moieties into the polymer backbone by co-polymerizing 2,4,6-tris(chloromethyl)-mesitylene with three diamines, namely 1,4-diaminobutane, m-phenylenediamine, and p-phenylenediamine. This process results in the stabilization of the amine moieties and the subsequently introduced nitroso groups. Charging bioactive nitric oxide (NO) into the polymers is accomplished by converting the amine moieties into N-nitroso groups. The ability of the polymers to store and release NO depends on their structures, particularly the amount of incorporated active secondary amines. With grafting photosensitive N-nitroso groups into the polymers, the derived NO@polymers exhibit photoresponsivity. NO release is completely regulated by adjusting UV light irradiation. These resulting polymeric NO donors demonstrate remarkable bactericidal and bacteriostatic activity, effectively eradicating E. coli bacteria and inhibiting their growth. The findings from this study hold promising implications for combining NO delivery with phototherapy in various medical applications.

Original languageEnglish
Article number2300473
JournalMacromolecular rapid communications
Issue number22
Early online date20 Sept 2023
Publication statusPublished - Nov 2023

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.


  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry
  • copolymers
  • nitric oxide
  • light irradiation
  • photoresponsivity
  • antibacterial materials


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